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Figure 2. Schematic diagram of proposed effect of cFLIP and Bcl-xL on NF-
B activation and muscle differentiation. cFLIP inhibits and Bcl-xL enhances NF-B activation in muscle cells when stimulated with cancer cytokines in vitro. The lower level of NF-B activation induced by expression of cFLIP was associated with rescue from failure of muscle cell differentiation. The higher level of NF-B activation induced by expression of Bcl-xL was associated with exacerbation of the failure of muscle cell differentiation. Dotted lines indicate that the mechanism by which cFLIP and Bcl-xL expression inhibits and enhances NF-B activation, respectively, is unknown. MRF, myosin regulatory factor.
