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Figure 3. Schematic representation of the signaling cascade in the formation of GroPIns in PCCl3 cells. Pathways initiated by adrenergic (
1, 2) and purinergic (P2Y2) receptor activation lead to PTX-sensitive activation of p38 and to PTX-insensitive activation of ERK1/2 (only for the adrenergic receptor) and PLC. These in turn either directly activate PLA2IV or produce an increase in [Ca2+]i; the latter promotes PLA2IV translocation to the membrane and ERKs activation. PLA2IV activation results in hydrolysis of PtdIns, release of arachidonic acid and LysoPtdIns, and finally, GroPIns production. See text for details.
