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Figure 1. Agonist-induced production of GroPIns is mediated by PLA₂IV in PCCl₃ cells. Cells preincubated for 15 min without (–) and with (+) pyrrophenone (Pyr; 0.1 µM) were stimulated with ATP (10 µM) and NE (20 µM) for another 15 min unless otherwise specified. A) Stimulation of [³H]-GroPIns production (means±SE; 4 independent experiments). B) Time courses showing pyrrophenone effects on control and NE-stimulated [³H]-GroPIns levels (% of initial control levels). C) Stimulation of [³H]-LysoPtdIns production (means±SE; 4 independent experiments). D) As for panel B for [³H]-LysoPtdIns. E) Stimulation of [³H]-arachidonic acid release (% of untreated Ctrl cells; means±SE; 3 independent experiments). F) ATP- and NE-mediated [³H]-arachidonic acid release with increasing concentrations of pyrrophenone (% of untreated cells). *Significantly different from respective controls (P0.05).

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