FASEB J.
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Figure 2


Figure 2. Inhibition of platelet-mediated foam cell formation from CD34+ cells and secretion of matrix metalloproteinase-9 by statins and PPAR agonists. CD34+ cells were coincubated with freshly isolated platelets in 96-well plates for 10 days. Cells were incubated with different statins. Fluvastatin, atorvastatin, and simvastatin (1 µM+10 µM) resulted in complete inhibition of foam cell generation whereas pravastatin (10 µM) was less potent.





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