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Figure 3. Schematic diagram of monocyte diapedesis through brain endothelium. A) Upon adhesion, monocytes approach endothelial cell-to-cell junctions, and B) induce local redistribution of occludin and C) formation of an endothelial gap. Occludin redistribution and endothelial gap formation involve proteolytic activity of a matrix metalloproteinase.
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