Click on image to view larger version.
Figure 2. The physical nature of mutant huntingtin is altered specifically in brain regions receiving dopaminergic input in DAT–/–,HdhQ92/Q92 mice. Examples of brain sections immunolabeled with EM-48 showing the aggregates of mutant huntingtin in the striatum (A), substantia nigra (B), and globus pallidus (C) of DAT+/+,HdhQ92/Q92 and DAT–/–,HdhQ92/Q92 mice. Neuronal nuclei are immunostained using NeuN antibodies (red) and the aggregates of mutant huntingtin using EM-48 (green). Representative sections were selected from 3 coronal sections per mice, 3 mice per genotype. Scale bar = 100 µm.
