FASEB J.
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Figure 3


Figure 3. Schematic diagram illustrating the formation and protective actions of DHA-derived lipid mediators in the liver. Protectin D1 and 17S-HDHA are novel bioactive lipid mediators derived from DHA with potent protective actions. These lipid signals may ameliorate necroinflammatory liver injury by reducing DNA damage and oxidative stress in hepatocytes and by down-regulating TNF-{alpha} release and 5-LO and COX-2 activities in macrophages (M{Phi}).





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