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Figure 1. Hybrid cardiomyocytes expressing both host (GFP) and hamster (surface antigen) markers in hamster hearts transplanted into GFP+ transgenic rats. A–D) Confocal images of GFP+ cardiomyocytes coexpressing GFP and cTnI (A, B) or GFP and sarcomeric MyHC (C, D) and showing the typical sarcomeric striation of mature muscle cells. E–H) Sections of normal hamster (E, F) and rat heart (G, H) stained with hematoxylin-eosin (E, G) or anti-hamster antiserum (F, H). Note specific surface membrane staining in hamster but not in rat cardiomyocytes. I, J) Representative GFP+ cardiomyocytes (green) present in the xenografts are labeled by anti-hamster antiserum (red). Scale bars: 30 µm.
