FASEB J.
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Figure 3


Figure 3. Schematic diagram of auto/paracrine actions of vitamin D in bone.The 25-(OH)D3-vitamin D binding protein (DBP) complex binds to its receptors cubilin and megalin on the membrane of osteoblasts and is internalized. The complex is dissociated and DBP degraded while 25-(OH)D3 is converted into 1{alpha},25-(OH)2D3 in the mitochondria. Next, 1{alpha},25-(OH)2D3 can bind to its receptor (VDR) and modify cellular activity. The eventual result shown in this manuscript is induction of CYP24 and osteocalcin mRNA expression, an increase in osteocalcin protein, alkaline phosphatase activity, and enhancement of mineralization.





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