FASEB J.
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Figure 2


Figure 2. Effect of TAPs on IGF-1R defective cells. Thrombin-activated platelets have been applied to parental NIH-3T3 cells and to clones stably overexpressing wt IGF-1R or IGF-1R-DN. A) Cells have been detached and counted. B, C) Alternatively, at the indicated times, cells have been solubilized and the activity of Akt/PKB and ERK1/2 determined. The graphs represent the means ± SD of three independent experiments in triplicate.





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