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Figure 1. Mesenteric inflammation induced by HP extract and effect of a CCK-2 receptor antagonist. Rats were treated chronically (days 1, 3, 5, and 7) with an aqueous extract of HP or saline, and the effects on leukocyte rolling flux (A), rolling velocity (B), adhesion (C), and emigration (D) were analyzed in mesenteric postcapillary venules on day 14. Animals were divided into 4 groups: saline + vehicle of proglumide (n=7), saline + proglumide (n=5), HP extract + vehicle of proglumide (n=5), and HP extract + proglumide (n=7). Results are mean ± SEM. *P < 0.05 and ***P < 0.001 vs. saline + vehicle of proglumide group; +P < 0.05 and ++P < 0.01 vs. HP extract + vehicle of proglumide group.
