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Figure 2. Schematic representation of the hClC-4 localization and of its function in the ER/SR. A) Schematic secondary structures of hClC-4 and hClC-3 are shown in red and in blue, respectively. At the C-terminus GFP is shown as a green icon. hClC-4 is inserted in the membrane of ER/SR and hClC-3 in the membrane of a vesicular compartment (V). B) Chimeras of hCLC-3 and hClC-4. The N-terminus of hClC-4 localizes hClC-3 to the ER/SR and the N-terminus of hClC-3 localizes hClC-4 to the vesicular compartment. The C-terminus of hClC-4 does not displace hClC-3 from its compartment. C) Schematic representation of the role of hClC-4 in the homeostatic control of [Ca2+].
