FASEB J. FASEB Summer Research Conferences
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Figure 3


Figure 3. Ca2+ entry through CRAC channels activates protein kinase C {alpha} and ßI, which then activate the MEK/ERK cascade. ERK, in turn, stimulates both cPLA2 and 5-lipoxygenase activities, generating intra-and intercellular messengers within minutes. Ca2+ influx through CRAC channels also activates gene transcription, operating over tens of minutes and occurring through an ERK-independent pathway.





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