FASEB J.
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Figure 2


Figure 2. Schematic diagram of the experimental findings. As glycosylated ECD{alpha}2 binds to IL-13 with high affinity, it effectively blocks IL-13-induced STAT6 phosphorylation, cell proliferation, protein synthesis, and IL-13 cytotoxin-induced cytotoxicity. N-linked glycosylation is critical for optimal inhibitory effect as deglycosylated ECD{alpha}2 demonstrated little effect on IL-13-induced STAT6 phosphorylation.





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