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Figure 2. OsM attenuates NMDA-mediated excitotoxic injury in vivo. The striatal region of mice was injected with NMDA alone or in the presence of vehicle (PBS+0.025% BSA) or 5 µg/ml OsM. 24 h later, the lesion volume was determined in 40 µm coronal sections that spanned the entire lesion. A) Representative sections showing the lesion produced after injection with NMDA alone (left panel) and with NMDA+OsM (right panel). The lesion appears as a darkened zone and the injection site (white arrows). White horizontal line in left image: 2 mm scale bar. B) Composite data showing the attenuating effect of OsM on NMDA-induced lesion volume (n=10 for NMDA; n=4 for NMDA+vehicle [PBS+ .025% BSA]; n=8 for NMDA+OsM). *Significant difference in lesion volume of NMDA+OsM treated group compared to mice injected with NMDA alone (P<0.001) and NMDA+vehicle (P<0.05).
