Click on image to view larger version.
Figure 3. Schematic presentation of in vivo cellular source of iNOS-derived NO in various inflammatory settings. BM transplantations between WT and iNOS–/– mice revealed that hematopoietic cells are fully responsible for systemic NO production during BCG infection. However, after TNF, LPS or Salmonella treatment, most, if not all, systemic NO originates from non-hematopoietic cells, which is in contrast with the general assumption, based on in vitro studies, that macrophages are the principle source of iNOS-derived NO during inflammatory shock.
