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(The FASEB Journal. 2006;20:2180.)
© 2006 FASEB

No association between polymorphism in PEMT (V175M) and hepatic triglyceride content in the Dallas Heart Study

Stefano Romeo1, Jonathan C. Cohen and Helen H. Hobbs

Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA

1Correspondence: Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA. E-mail: stefano.romeo{at}utsouthwestern.edu.

A nonsynonymous sequence variation (V175M) in PEMT, the gene encoding phosphatidylethanolamine N-methyltransferase, was recently reported in The FASEB Journal to be associated with nonalcoholic fatty liver disease (NAFLD) (1) . The frequency of the 175M allele was significantly higher in 28 subjects with biopsy-confirmed NAFLD (23 Whites, 2 Blacks, 1 Hispanic, and 1 Asian) than in 59 subjects who had a normal hepatic triglyceride content (HTGC) by magnetic resonance imaging (MRI) (n=47) or by liver biopsy (n=12) (37 Whites, 14 Blacks, 3 Hispanics, 3 Asians, 1 Native American, and 1 Trinidadian, 67.9% vs. 40.7%; P<0.03).

We analyzed the association between the V175M allele (~523 G>A) and hepatic triglyceride content (HTGC) in the Dallas Heart Study (DHS), a multiethnic population-based probability sample of Dallas County, Texas (2) , in which ethnicity was self-reported. A total of 2349 Dallas Heart Study participants underwent proton magnetic resonance spectroscopy (1H-MRS) of the liver to quantify the HTGC after informed consent was obtained (3) . Hepatic steatosis was defined as a HTGC exceeding the 95th percentile (HTGC>5.5%) when compared to healthy subjects with no evidence of hepatic disease (2) . The alleles of the polymorphism were in Hardy Weinberg equilibrium (HWE) in all three ethnic groups (data not shown) and were not associated with HTGC or hepatic steatosis in any group, even after adjusting for BMI (Table 1 ). These data fail to support an association between the V175M allele and HTGC.


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  		Table 1. Relationship between SNP at PEMT (~523 G>A), hepatic triglyceride content (HTGC) in the Dallas Heart Study

REFERENCES

  1. Song, J., da Costa, K. A., Fischer, L. M., Kohlmeier, M., Kwock, L., Wang, S., Zeisel, S. H. (2005) Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD). FASEB J. 19,1266-1271[Abstract/Free Full Text]
  2. Victor, R. G., Haley, R. W., Willett, D. L., Peshock, R. M., Vaeth, P. C., Leonard, D., Basit, M., Cooper, R. S., Iannacchione, V. G., Visscher, W. A., Staab, J. M., Hobbs, H. H., . Dallas Heart Study Investigators (2004) The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health. Am. J. Cardiol. 93,1473-1480[CrossRef][Medline]
  3. Szczepaniak, L. S., Nurenberg, P., Leonard, D., Browning, J. D., Reingold, J. S., Grundy, S., Hobbs, H. H., Dobbins, R. L. (2005) Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am. J. Physiol. 288,E462-E468

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