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Figure 3. Schematic representation of the differential tissue-specific effects of ZK191784 compared with 1,25(OH)2D3 regarding Ca2+ homeostasis and expression of Ca2+ transporters. ZK191784 inhibits 1,25(OH)2D3-stimulated Ca2+ absorption in vivo and in the intestinal Caco-2 cell line and down-regulates 1,25(OH)2D3-stimulated intestinal Ca2+ transporter expression. ZK191784 and 1,25(OH)2D3 both display stimulatory effects in vivo on Ca2+ reabsorption and renal Ca2+ transporter expression as well as in primary cultures of immunodissected rabbit kidney CNT and CCD cells. Furthermore, ZK191784 and 1,25(OH)2D3 stimulate osteocalcin secretion by ROS17/2.8 cells.
