FASEB J. Experimental Biology 2009
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Figure 3


Figure 3. A schematic of the proposed events that lead to clinical weakness in the MLC1/3-ßAPP mice. Overexpression of human WT ßAPP with age results in Aß accumulation into inclusions in type II fast twitch skeletal muscle. Intramyofiber accumulation of ß-amyloid into inclusions is associated with loss of membrane depolarization, an increase in the level of resting calcium, and degeneration of skeletal muscle.





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