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Figure 2. Accelerated atherosclerosis in WHHL rabbit model of diabetes and dyslipidemia. It has been hypothesized that in diabetes there is an induction of VEGF-A and VEGF-D expression through a pathway involving RAGE and NF-
B that enhances inflammation and plaque vascularization. Macrophages also contribute to accelerated atherosclerosis in diabetic rabbits.
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