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Figure 1. Immunohistochemical analysis of atherosclerotic lesions in diabetic rabbits. A) RAM-11 immunostaining for macrophages was significantly increased in the 6 month subgroup. B) HHF-35 immunostaining for smooth muscle cells in diabetic and control rabbits was similar. C) Areas of RAGE and D) NF-
B p65 immunostainings were significantly increased in diabetic rabbits. E) VEGF-A staining was significantly increased in diabetic rabbits at both time points whereas F) VEGF-D staining was increased only at the 6 month time point. G) A significant increase in VEGFR-2 and (H) VEGFR-1 immunostaining was present at the 6 month time point in diabetic rabbits. I) The number of capillaries in the atherosclerotic lesions of the diabetic rabbits tended to be increased compared with controls, but the difference was not statistically significant. *P < 0.05; **P < 0.01; ***P < 0.001.
