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Figure 3. Schematic diagram of sema 3C functions and signaling in endothelial cells. Sema 3C is produced and secreted by endothelial cells (1). Sema 3C binds to its neuropilin-plexin receptor complex and induces integrin activation, specifically ß1 integrin Ser-785 phosphorylation (2), and increases VEGF120 secretion to the media by NP2-dependent and VEGFR2- and integrin-independent mechanism (3). Solid arrow indicates a proven mechanism and dashed arrow, a possible mechanism. Sema 3C signaling stimulates endothelial cell (EC) adhesion, migration, and capillary-like tube formation and promotes EC proliferation and survival.
