FASEB J. Experimental Biology 2009
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Figure 3


Figure 3. Schematic diagram of apoptotic mechanism induced by gossypol. We found that gossypol induces Bax/Bak independent apoptosis. It can directly impact on mitochondria to induce the reduction of {Delta}{psi}m and cytochrome c release without affecting mPTP opening. Our results showed that the interaction between gossypol with Bcl-2 and the subsequent Bcl-2 conformational change play critical roles for the apoptotic effects.





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