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Figure 3. Molar content of PDYN and mature peptide products in rat dentate gyrus and striatum where somata of PDYN-containing neurons are located and in CA3 subfield of the hippocampus and VTA that both receive projections of PDYN-containing neurons. Activation of PDYN processing occurred by cell depolarization. A) WB with affinity-purified antirCTF PDYN antibodies. B) Molar content of PDYN and peptide products of this protein Dyn A, Dyn B, and Leu-enkephalin-Arg. C) Changes in relative levels of PDYN, Dyn A, Dyn B, and Leu-enkephalin-Arg in the CA3 subfield of the hippocampus 90 min after ip administration of kainic acid. Mean ± SE (n=10/group) of relative peptide levels is shown; levels in control group were taken as a unit. Student’s t test was used for evaluation of statistical significance of differences; **P < 0.01; ***P < 0.001.
