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Figure 2. Prolonged STAT1 activation with IFN-
overcomes the cardioprotective effects of tempol. A) Infarct size was measured in rats subjected to the surgical procedure alone (sham n=5) or to LAD coronary artery occlusion (25 min) and reperfusion (2 h) with infusion (5 min before reperfusion) of either saline (I/R n=7), tempol (n=7), IFN- (n=6), or tempol and IFN- together (n=6). *P < 0.05 compared with I/R vehicle. B) Western blot analysis of STAT1 phosphorylation from hearts tissues extracted from the experiment of panel A. Similar blots were observed from 3 different hearts form each group.
