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Figure 3. Possible interactions of IL-10R signaling to modules affecting TNF gene expression. LPS binding/receptor complex leads to the transmission of p38MAPK signals activating TNF mRNA stability/ translation (open circles and arrows). At similar or consecutive time points, it leads to the activation of stability and translation determining factors that act in a negative fashion, apparently via p38-independent mechanisms (gray shaded circles and arrows). On the other hand, IL-10 receptor engagement may transmit signals toward SOCS3 activation, building up a negative regime targeting p38/MK2 activating signals toward ARE-dependent TNF mRNA stability/translation, likely mediated by the selective binding of various transfactors such as TTP (translation) and HuR (mRNA stability).
