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Figure 2. TACE-induced RIP of p75NTR enhanced DRGN neurite outgrowth in the presence/absence of CNS myelin ligands. Quantification of mean longest DRGN neurite lengths (±SD) demonstrated significantly enhanced FGF2-stimulated DRGN neurite outgrowth after addition of TACE + FGF + CNS myelin. Addition of TIMP3 blocked TACE-mediated DRGN neurite outgrowth. ***P < 0.0001. *P < 0.05.
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