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Figure 1. T-oligo accelerates the removal of CPDs. A) Representative images of skin explants from a 77-year-old donor were pretreated with diluent or T-oligo for 24 h, followed by UVB irradiation. Skin was harvested at various times post-UV and was immunostained with anti-CPD antibodies. B) Quantification of CPD (+). CPD (+) nuclei were counted in at least 3–5 randomly selected areas of 100 µm of linear epidermis in explants from 10 donors/treatment condition for each time point. The number of initial CPDs (time 0) was similar in all groups and designated as 100%. CPD (+) nuclei after 4, 24, 48, and 72 h are shown for diluent-treated (gray bars) vs. T-oligo-treated (open bars) epidermis. C, control; D, diluent; T, T-oligo.
