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Figure 1. Urocortin III is more potent than the CRF1-preferring ligand, CRF, and its effects are blocked by a CRF2-specific antagonist. A) Comparison of the concentration-relaxation relationship for urocortin III (n=6) and CRF (n=4) in the mouse trachea. CRF is significantly less potent (P=0.02) than urocortin III, although it has similar efficacy. B) Effect of different concentrations (1 nM to 100 nM) of the CRF2 antagonist astressin 2B on the concentration-relaxation relationship. n = 4 for each concentration of astressin 2B; n = 16 in the control group.
