The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis FASEB J. Broderick et al.
20: 1865
Supplemental Data
Files in this Data Supplement:
Supplemental Figure 1 -
(SuppFigure1.pdf; 818 KB) Shown is the structure of cobalamin. Cobinamide lacks the dimethylbenzimidazole ribonucleotide tail attached to the cobalt atom in the lower axial position. The "R" group can be any number of ligands, including nitric oxide.
Supplemental Table 1 -
(SuppTable1.pdf; 42 KB) Free NO at Various NO and Cobinamide Concentrations Free NO concentrations under each condition was calculated using the COMICSprogram
