FASEB J.
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Figure 3


Figure 3. Proposed signaling pathway by which interaction of resveratrol with integrin {alpha}Vß3 in the plasma membrane of cancer cells leads to cancer cell apoptosis. Resveratrol (RV) binds primarily to the ß3 monomer of the integrin, activating the ERK1/2 pathway with consequent phosphorylation of serine-15 of p53. Nuclear phosphorylated p53 accumulates, leading to stimulation of p53-responsive gene transcription and apoptosis of breast cancer cells.





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