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Figure 3. Schematic summary and putative model: On exposure to OPs, PON protects AChE by degrading the poison and reducing the threat of oxidative damage (left). The surplus OPs that remain active after the physiological protective response inhibit AChE and cause an increase in ACh, leading to a feedback response that overproduces AChE as well as to activation (red areas) or suppression (blue) of brain activity (brain cartoon). The entire biochemical and neurophysiological response to exposure is dependent on the genetic profile of the individual (i.e., on PON1 polymorphism and varies with the brain region examined).
