FASEB J.
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Figure 3


Figure 3. Proposed mechanism of NO-mediated glutathiolation. NO generated from eNOS or iNOS S-nitrosylates proteins (PSH), and reduced GSH could assist in the denitrosylation and the glutathiolation of specific proteins. Alternatively, GSNO may directly glutathiolate target proteins. Glutathiolation could regulate protein function and/or protect protein thiols from irreversible oxidation.





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