Click on image to view larger version.
Figure 3. Schematic showing the matricellular growth regulator CTGF as it interacts with cell surface receptors in a context-dependent manner, activating the PI-3 kinase pathway (1). Akt/PKB then phosphorylates p27 at two sites, serine 10 and threonine 157, resulting in cytoplasmic translocation and stabilization (2), where it binds to and inactivates RhoA (3), resulting in uncoupling of RhoA from the Lim kinase/cofilin pathway and increased actin severing activity leading to actin depolymerization (4).
