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Figure 2. The left side of diagram shows a proposed pathway by which lack of hypoxia-inducible factor (HIF) contributes to development of bronchopulmonary dysplasia (BPD). The right side of the diagram shows a proposed pathway of how HIF-stabilization through inhibition of prolyl hydroxylase domain-containing proteins (PHDs) by FG-4095 treatment restores lung growth and function. ARNT, aryl hydrocarbon receptor nuclear translocator; Flt-1 and KDR, VEGF receptors; HRE, hypoxia response element; OG, 2-oxoglutarate; OH, hydroxylation; PECAM-1, platelet-endothelial cell adhesion molecule 1; pVHL, product of von Hippel Lindau gene; Uq, ubiquitin; VEGF, vascular endothelial growth factor..
