Supplemental Data

Files in this Data Supplement:

• Supplemental Figure - Lovastatin treatment attenuates inflammatory demyelination in the spinal cord of EAE animals. EAE induction and lovastatin treatment was performed as described under ‘Materials & Methods’. Data are shown as average clinical disease scores. Age matched lovastatin-treated EAE (E+LOV) and control (C+LOV), and untreated EAE (EAE) and control animals were sacrificed on peak clinical day (13th dpi) and on remission (20th dpi). Graphs represent the clinical scores and body weight profile in animals from each group after days of post immunization (A-B). Representative spinal cord tissues sections stained with LFB from control (C) and EAE (D) demonstrating severe demyelination (arrowheads) in white matter region (40x). Representative sections, stained with both LFB and H&E stains from each group animals depict a typical inflammatory infiltration (arrowheads) and demyelination in the white matter (400x) (E). The asterisks denote *** p<0.01 versus E+LOV.