The antipsoriatic drug anthralin accumulates in keratinocyte mitochondria, dissipates mitochondrial membrane potential, and induces apoptosis through a pathway dependent on respiratory competent mitochondria FASEB J. McGill et al.
10.1096/fj.04-2664fje
Supplemental Data
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Supplemental Figures S1-S5 -
(McGillSupplFigsS1-S5.pdf; 369 KB) Figure S1 and S2: Localisation of cytochrome c to mitochondria in HaCaT keratinocytes. Figure S3: Cyclosporin inhibis mitochondrial permeability transition but not dithranol-induced dissipation of mitochondrial membrane potential in HaCaT keratinocytes. Figure S4: Anthralin induces perinuclear clustering of mitochondria, cytochrome c release and apoptotic cell death in HaCaT keratinocytes Figure S5: 143B ρ0