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The FASEB Journal, Vol 9, 799-806, Copyright © 1995 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Induction and variants of neuronal nitric oxide synthase type I during synaptogenesis

P Ogilvie, K Schilling, ML Billingsley and HH Schmidt
Medizinische Universitatsklinik, Klinische Biochemie und Pathobiochemie, Wurzburg, Germany.

In the adult central nervous system, nitric oxide (NO) is formed from L- arginine by the so-called constitutive or type I NO synthase (NOS- I155). However, expression of NOS-I155 immunoreactivity and activity was low or not detectable in developing mouse and rat brain. NOS-I155 was sharply induced coincident with the onset of synaptogenesis in specific brain regions. This was followed by a second phase in which total NOS-I155 expression decreased both in specific cell populations and in the total synaptosomal subcellular fraction.Furthermore, two putative variants of NOS-I were transiently observed: an NOS-I- immunoreactive protein with increased electrophoretic mobility (NOS- I144) and a transient hypersensitivity of NOS-I155 to the competitive substrate inhibitor N omega-nitro-L-arginine. It is concluded that NOS- I expression is not constitutive but locally induced. In the central nervous system, this regionally specific, biphasic pattern of postnatal NOS-I induction is consistent with a role for NO in synaptogenesis and synaptic plasticity.


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