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The FASEB Journal, Vol 9, 1331-1335, Copyright © 1995 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

High-affinity binding of melatonin by human circulating T lymphocytes (CD4+)

MG Gonzalez-Haba, S Garcia-Maurino, JR Calvo, R Goberna and JM Guerrero
Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine, Spain.

This paper shows the presence of high-affinity binding sites for melatonin in human circulating T lymphocytes, but not in B lymphocytes. The binding of melatonin to T cells was dependent on time, stable, reversible, saturable, specific, and inversely correlated to the production of melatonin, expressed as the nocturnal 12 h production of its urinary metabolite 6-sulfatoxymelatonin. The affinity of these binding sites (Kd = 0.27 nM) suggests that they may recognize the physiological concentrations of melatonin in serum. Moreover, among the lymphocyte subpopulations studied, binding of melatonin was mostly found in CD4+ cells rather than in CD8+ cells. Results suggest that CD4+ cells may be the target of melatonin among the human circulating lymphocytes.


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Copyright © 1995 by The Federation of American Societies for Experimental Biology.