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The FASEB Journal, Vol 9, 1297-1303, Copyright © 1995 by The Federation of American Societies for Experimental Biology


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Regulation of cellular calcium through signaling cross-talk involves an intricate interplay between the actions of receptors, G-proteins, and second messengers

FL Bygrave and HR Roberts
Division of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, Australia.

Various external stimuli regulate cellular Ca2+ fluxes. Information from these stimuli is transmitted to the cell interior by signal transducing systems that involve interactions between receptors, G- proteins, and enzymes that generate second messengers. The possible mechanisms by which "cross-talk" within and between these second messenger-generating systems provides an intricate molecular avenue for fine modulation of intracellular Ca2+ are reviewed.


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