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The FASEB Journal, Vol 9, 919-925, Copyright © 1995 by The Federation of American Societies for Experimental Biology

REVIEWS

Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction

RE Friesel and T Maciag
Department of Molecular Biology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA.

The fibroblast growth factors are a family of structurally related polypeptides that are mitogenic for a broad range of cell types as well as mediators of a wide spectrum of developmental and pathophysiological processes in vivo and in vitro. The fibroblast growth factor family presently consists of nine distinct members. Indeed, the FGF prototypes FGF-1 (acidic) and FGF-2 (basic) are well described as modifiers of angiogenesis. The absence of a signal sequence to direct their secretion and their ability to traffic to the nucleus are unique structural features that may be relevant to the regulation of their activities. The FGF receptor family consists of four transmembrane receptor tyrosine kinases. Each of these receptors give rise to multiple isoforms as a result of alternative splicing of their mRNAs. The significance of these multiple isoforms is not fully understood; however it is known that alternative splicing in the extracellular domain of these receptors results in altered ligand binding specificities. In addition, alternative splicing in the cytoplasmic domain results in isoforms with increased oncogenic potential. This review will describe recent insights into the pathways used for the regulation of FGF secretion and cellular trafficking as well as signaling by FGFRs.


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[Abstract] [Full Text]

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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text]

Home page
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[Abstract] [Full Text]

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Home page
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[Full Text] [PDF]

Home page
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[Abstract] [Full Text]

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[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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J. Biol. Chem., March 24, 2000; 275(13): 9581 - 9586.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
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Uncoupling of cell proliferation and differentiation activities of basic fibroblast growth factor
FASEB J, February 1, 2000; 14(2): 333 - 344.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
M. V. Cronauer, S. Stadlmann, H. Klocker, B. Abendstein, I. E. Eder, H. Rogatsch, A. G. Zeimet, C. Marth, and F. A. Offner
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
R. G. Pestell, C. Albanese, A. T. Reutens, J. E. Segall, R. J. Lee, and A. Arnold
The Cyclins and Cyclin-Dependent Kinase Inhibitors in Hormonal Regulation of Proliferation and Differentiation
Endocr. Rev., August 1, 1999; 20(4): 501 - 534.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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Effects of Mutations of a Phosphorylation Site in an Exposed Loop in Acidic Fibroblast Growth Factor
J. Biol. Chem., June 18, 1999; 274(25): 18081 - 18086.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
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[Abstract] [Full Text] [PDF]

Home page
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Molecular characteristics of fibroblast growth factor-fibroblast growth factor receptor-heparin-like glycosaminoglycan complex
PNAS, March 30, 1999; 96(7): 3658 - 3663.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
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Circ. Res., February 19, 1999; 84(3): 323 - 328.
[Abstract] [Full Text] [PDF]

Home page
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Development, January 10, 1999; 126(20): 4465 - 4475.
[Abstract] [PDF]

Home page
 Mol. Endocrinol.Home page
X. Zhang, G. A. Horwitz, T. R. Prezant, A. Valentini, M. Nakashima, M. D. Bronstein, and S. Melmed
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Mol. Endocrinol., January 1, 1999; 13(1): 156 - 166.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
C. M. Carreira, T. M. LaVallee, F. Tarantini, A. Jackson, J. T. Lathrop, B. Hampton, W. H. Burgess, and T. Maciag
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J. Biol. Chem., August 28, 1998; 273(35): 22224 - 22231.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. L. Panek, G. H. Lu, T. K. Dahring, B. L. Batley, C. Connolly, J. M. Hamby, and K. J. Brown
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Home page
 Biol. Reprod.Home page
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