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The FASEB Journal, Vol 9, 899-909, Copyright © 1995 by The Federation of American Societies for Experimental Biology

REVIEWS

Transcriptional regulation of endothelial cell adhesion molecules: NF- kappa B and cytokine-inducible enhancers

T Collins, MA Read, AS Neish, MZ Whitley, D Thanos and T Maniatis
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Transcription of endothelial-leukocyte adhesion molecule-1 (E-selectin or ELAM-1), vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) is induced by the inflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF alpha). The positive regulatory domains required for maximal levels of cytokine induction have been defined in the promoters of all three genes. DNA binding studies reveal a requirement for nuclear factor-kappa B (NF-kappa B) and a small group of other transcriptional activators. The organization of the cytokine- inducible element in the E-selectin promoter is remarkably similar to that of the virus-inducible promoter of the human interferon-beta gene in that both promoters require NF-kappa B, activating transcription factor-2 (ATF-2), and high mobility group protein I(Y) for induction. Based on this structural similarity, a model has been proposed for the cytokine-induced E-selectin enhancer that is similar to the stereospecific complex proposed for the interferon-beta gene promoter. In these models, multiple DNA bending proteins facilitate the assembly of higher order complexes of transcriptional activators that interact as a unit with the basal transcriptional machinery. The assembly of unique enhancer complexes from similar sets of transcriptional factors may provide the specificity required to regulate complex patterns of gene expression and correlate with the distinct patterns of expression of the leukocyte adhesion molecules.


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 Arterioscler. Thromb. Vasc. Bio.Home page
D. T. Bolick, S. Srinivasan, K. W. Kim, M. E. Hatley, J. J. Clemens, A. Whetzel, N. Ferger, T. L. Macdonald, M. D. Davis, P. S. Tsao, et al.
Sphingosine-1-Phosphate Prevents Tumor Necrosis Factor-{alpha}-Mediated Monocyte Adhesion to Aortic Endothelium in Mice
Arterioscler Thromb Vasc Biol, May 1, 2005; 25(5): 976 - 981.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. J. Garcia-Vallejo, W. van Dijk, I. van Die, and S. I. Gringhuis
Tumor Necrosis Factor-{alpha} Up-regulates the Expression of {beta}1,4-Galactosyltransferase I in Primary Human Endothelial Cells by mRNA Stabilization
J. Biol. Chem., April 1, 2005; 280(13): 12676 - 12682.
[Abstract] [Full Text] [PDF]

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 Mol. Pharmacol.Home page
N. Matsuda, Y. Hattori, S. Jesmin, and S. Gando
Nuclear Factor-{kappa}B Decoy Oligodeoxynucleotides Prevent Acute Lung Injury in Mice with Cecal Ligation and Puncture-Induced Sepsis
Mol. Pharmacol., April 1, 2005; 67(4): 1018 - 1025.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
L. C. Edelstein, A. Pan, and T. Collins
Chromatin Modification and the Endothelial-specific Activation of the E-selectin Gene
J. Biol. Chem., March 25, 2005; 280(12): 11192 - 11202.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
C.-R. Yang, S.-L. Hsieh, F.-M. Ho, and W.-W. Lin
Decoy Receptor 3 Increases Monocyte Adhesion to Endothelial Cells via NF-{kappa}B-Dependent Up-Regulation of Intercellular Adhesion Molecule-1, VCAM-1, and IL-8 Expression
J. Immunol., February 1, 2005; 174(3): 1647 - 1656.
[Abstract] [Full Text] [PDF]

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 J. Nutr.Home page
V. Stangl, M. Lorenz, A. Ludwig, N. Grimbo, C. Guether, W. Sanad, S. Ziemer, P. Martus, G. Baumann, and K. Stangl
The Flavonoid Phloretin Suppresses Stimulated Expression of Endothelial Adhesion Molecules and Reduces Activation of Human Platelets
J. Nutr., February 1, 2005; 135(2): 172 - 178.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
H. Ogawa, D. G. Binion, J. Heidemann, M. Theriot, P. J. Fisher, N. A. Johnson, M. F. Otterson, and P. Rafiee
Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells
Am J Physiol Cell Physiol, February 1, 2005; 288(2): C272 - C281.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C.-H. Woo, J.-H. Lim, and J.-H. Kim
VCAM-1 upregulation via PKC{delta}-p38 kinase-linked cascade mediates the TNF-{alpha}-induced leukocyte adhesion and emigration in the lung airway epithelium
Am J Physiol Lung Cell Mol Physiol, February 1, 2005; 288(2): L307 - L316.
[Abstract] [Full Text] [PDF]

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 Exp Biol MedHome page
M. E. Jung, M. B. Gatch, and J. W. Simpkins
Estrogen Neuroprotection Against the Neurotoxic Effects of Ethanol Withdrawal: Potential Mechanisms
Exp Biol Med, January 1, 2005; 230(1): 8 - 22.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
J. Wang, R. A. Barke, R. Charboneau, and S. Roy
Morphine Impairs Host Innate Immune Response and Increases Susceptibility to Streptococcus pneumoniae Lung Infection
J. Immunol., January 1, 2005; 174(1): 426 - 434.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Rahman, K. N. Anwar, Mohd. Minhajuddin, K. M. Bijli, K. Javaid, A. L. True, and A. B. Malik
cAMP targeting of p38 MAP kinase inhibits thrombin-induced NF-{kappa}B activation and ICAM-1 expression in endothelial cells
Am J Physiol Lung Cell Mol Physiol, November 1, 2004; 287(5): L1017 - L1024.
[Abstract] [Full Text] [PDF]

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 Infect. Immun.Home page
C. Nakasone, K. Kawakami, T. Hoshino, Y. Kawase, K. Yokota, K. Yoshino, K. Takeda, S. Akira, and A. Saito
Limited Role for Interleukin-18 in the Host Protection Response to Pulmonary Infection with Pseudomonas aeruginosa in Mice
Infect. Immun., October 1, 2004; 72(10): 6176 - 6180.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
M. Akaike, W. Che, N.-L. Marmarosh, S. Ohta, M. Osawa, B. Ding, B. C. Berk, C. Yan, and J.-i. Abe
The Hinge-Helix 1 Region of Peroxisome Proliferator-Activated Receptor {gamma}1 (PPAR{gamma}1) Mediates Interaction with Extracellular Signal-Regulated Kinase 5 and PPAR{gamma}1 Transcriptional Activation: Involvement in Flow-Induced PPAR{gamma} Activation in Endothelial Cells
Mol. Cell. Biol., October 1, 2004; 24(19): 8691 - 8704.
[Abstract] [Full Text] [PDF]

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 Physiol. Rev.Home page
R. Stocker and J. F. Keaney Jr.
Role of Oxidative Modifications in Atherosclerosis
Physiol Rev, October 1, 2004; 84(4): 1381 - 1478.
[Abstract] [Full Text] [PDF]

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 Arterioscler. Thromb. Vasc. Bio.Home page
L. G. Melo, M. Gnecchi, A. S. Pachori, D. Kong, K. Wang, X. Liu, R. E. Pratt, and V. J. Dzau
Endothelium-Targeted Gene and Cell-Based Therapies for Cardiovascular Disease
Arterioscler Thromb Vasc Biol, October 1, 2004; 24(10): 1761 - 1774.
[Abstract] [Full Text] [PDF]

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 BloodHome page
Y. Katayama, A. Hidalgo, A. Peired, and P. S. Frenette
Integrin {alpha}4{beta}7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation
Blood, October 1, 2004; 104(7): 2020 - 2026.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
D. G. Zisoulis and G. S. Kansas
H-Ras and Phosphoinositide 3-Kinase Cooperate to Induce {alpha}(1,3)-Fucosyltransferase VII Expression in Jurkat T Cells
J. Biol. Chem., September 17, 2004; 279(38): 39495 - 39504.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
Y.-F. Xia, B.-Q. Ye, Y.-D. Li, J.-G. Wang, X.-J. He, X. Lin, X. Yao, D. Ma, A. Slungaard, R. P. Hebbel, et al.
Andrographolide Attenuates Inflammation by Inhibition of NF-{kappa}B Activation through Covalent Modification of Reduced Cysteine 62 of p50
J. Immunol., September 15, 2004; 173(6): 4207 - 4217.
[Abstract] [Full Text] [PDF]

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 J. Virol.Home page
T. Vincent, R. F. Pettersson, R. G. Crystal, and P. L. Leopold
Cytokine-Mediated Downregulation of Coxsackievirus-Adenovirus Receptor in Endothelial Cells
J. Virol., August 1, 2004; 78(15): 8047 - 8058.
[Abstract] [Full Text] [PDF]

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 FASEB J.Home page
K. V. RAMANA, A. BHATNAGAR, and S. K. SRIVASTAVA
Inhibition of aldose reductase attenuates TNF-{alpha}-induced expression of adhesion molecules in endothelial cells
FASEB J, August 1, 2004; 18(11): 1209 - 1218.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
D. K. Kaul, X.-d. Liu, S. Choong, J. D. Belcher, G. M. Vercellotti, and R. P. Hebbel
Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice
Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H293 - H301.
[Abstract] [Full Text] [PDF]

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 Cardiovasc ResHome page
Y. Onai, J.-i. Suzuki, T. Kakuta, Y. Maejima, G. Haraguchi, H. Fukasawa, S. Muto, A. Itai, and M. Isobe
Inhibition of I{kappa}B phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury
Cardiovasc Res, July 1, 2004; 63(1): 51 - 59.
[Abstract] [Full Text] [PDF]

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 J. Virol.Home page
C. Dai, R. E. McAninch, and R. E. Sutton
Identification of Synthetic Endothelial Cell-Specific Promoters by Use of a High-Throughput Screen
J. Virol., June 15, 2004; 78(12): 6209 - 6221.
[Abstract] [Full Text] [PDF]

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 J. Pharmacol. Exp. Ther.Home page
K. Tsunemi, S. Takai, M. Nishimoto, D. Jin, M. Sakaguchi, M. Muramatsu, A. Yuda, S. Sasaki, and M. Miyazaki
A Specific Chymase Inhibitor, 2-(5-Formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[{3,4-dioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl]acetamide (NK3201), Suppresses Development of Abdominal Aortic Aneurysm in Hamsters
J. Pharmacol. Exp. Ther., June 1, 2004; 309(3): 879 - 883.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
J. Cortes, D. Thomas, C. Koller, F. Giles, E. Estey, S. Faderl, G. Garcia-Manero, D. McConkey, G. Patel, R. Guerciolini, et al.
Phase I Study of Bortezomib in Refractory or Relapsed Acute Leukemias
Clin. Cancer Res., May 15, 2004; 10(10): 3371 - 3376.
[Abstract] [Full Text] [PDF]

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 Arterioscler. Thromb. Vasc. Bio.Home page
R. C. Braun-Dullaeus, M. J. Mann, D. G. Sedding, S. W. Sherwood, H. E. von der Leyen, and V. J. Dzau
Cell Cycle-Dependent Regulation of Smooth Muscle Cell Activation
Arterioscler Thromb Vasc Biol, May 1, 2004; 24(5): 845 - 850.
[Abstract] [Full Text]

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 J. Nutr.Home page
J.-S. Choi, Y.-J. Choi, S.-H. Park, J.-S. Kang, and Y.-H. Kang
Flavones Mitigate Tumor Necrosis Factor-{alpha}-Induced Adhesion Molecule Upregulation in Cultured Human Endothelial Cells: Role of Nuclear Factor-{kappa}B
J. Nutr., May 1, 2004; 134(5): 1013 - 1019.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Maaser, J. Heidemann, C. von Eiff, A. Lugering, T. W. Spahn, D. G. Binion, W. Domschke, N. Lugering, and T. Kucharzik
Human Intestinal Microvascular Endothelial Cells Express Toll-Like Receptor 5: A Binding Partner for Bacterial Flagellin
J. Immunol., April 15, 2004; 172(8): 5056 - 5062.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Sasaki, J. W. Elrod, P. Jordan, M. Itoh, T. Joh, A. Minagar, and J. S. Alexander
CYP450 dietary inhibitors attenuate TNF-{alpha}-stimulated endothelial molecule expression and leukocyte adhesion
Am J Physiol Cell Physiol, April 1, 2004; 286(4): C931 - C939.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
M. P. Soares, M. P. Seldon, I. P. Gregoire, T. Vassilevskaia, P. O. Berberat, J. Yu, T.-Y. Tsui, and F. H. Bach
Heme Oxygenase-1 Modulates the Expression of Adhesion Molecules Associated with Endothelial Cell Activation
J. Immunol., March 15, 2004; 172(6): 3553 - 3563.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. R. Dana
Corneal Antigen-Presenting Cells: Diversity, Plasticity, and Disguise The Cogan Lecture
Invest. Ophthalmol. Vis. Sci., March 1, 2004; 45(3): 722 - 727.
[Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
L. Wu, M. Iwai, Z. Li, T. Shiuchi, L.-J. Min, T.-X. Cui, J.-M. Li, M. Okumura, C. Nahmias, and M. Horiuchi
Regulation of Inhibitory Protein-{kappa}B and Monocyte Chemoattractant Protein-1 by Angiotensin II Type 2 Receptor-Activated Src Homology Protein Tyrosine Phosphatase-1 in Fetal Vascular Smooth Muscle Cells
Mol. Endocrinol., March 1, 2004; 18(3): 666 - 678.
[Abstract] [Full Text] [PDF]

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 Eur J Heart FailHome page
A. Matsumori, Y. Nunokawa, A. Yamaki, K. Yamamoto, M.-W. Hwang, T. Miyamoto, M. Hara, R. Nishio, K. Kitaura-Inenaga, and K. Ono
Suppression of cytokines and nitric oxide production, and protection against lethal endotoxemia and viral myocarditis by a new NF-{kappa}B inhibitor
Eur J Heart Fail, March 1, 2004; 6(2): 137 - 144.
[Abstract] [Full Text] [PDF]

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 Cardiovasc ResHome page
C. Monaco and E. Paleolog
Nuclear factor {kappa}B: a potential therapeutic target in atherosclerosis and thrombosis
Cardiovasc Res, March 1, 2004; 61(4): 671 - 682.
[Abstract] [Full Text] [PDF]


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