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The FASEB Journal, Vol 8, 504-512, Copyright © 1994 by The Federation of American Societies for Experimental Biology


REVIEWS

Adhesion molecules and inflammatory injury

SM Albelda, CW Smith and PA Ward
Department of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104.

Neutrophil-endothelial cell interactions are mediated by interacting sets of cell adhesion molecules (CAMs) and chemoattractant/activator molecules to form an "adhesion cascade." The initial phase of inflammation, a transient slowing of neutrophils in postcapillary venules, is mediated by selectins. Subsequently, firm adhesion of neutrophils to the vessel wall occurs via interaction of the CD11/CD18 (beta 2) integrins to endothelial ligands such as intercellular adhesion molecule-1 (ICAM-1). This binding requires activation of CD11/CD18 by exposure of the neutrophil to a variety of activating/chemoattractant molecules, such as platelet-activating factor or interleukin-8. Finally, transmigration into tissues occurs, a process that requires both a chemotactic stimulus and engagement of platelet-endothelial cell adhesion molecule-1 (PECAM-1). Several approaches have been used to probe the role of CAMs in vivo. These include the use of blocking antibodies, chimeric selectin- immunoglobulin proteins, sialyl Lewisx oligosaccharides and peptides, along with the study of humans and animals with genetically determined adhesion deficiencies. These studies demonstrate that CAM blockade can effectively inhibit inflammation; however, there appear to be clear differences in the adhesion requirements for particular types of inflammation. By understanding the CAM/chemoattractant profiles involved in specific disease states, it may be possible to precisely and effectively target therapy to a wide variety of inflammatory diseases.


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C. D. Kim, Y. K. Kim, S. H. Lee, and K. W. Hong
Rebamipide Inhibits Neutrophil Adhesion to Hypoxia/Reoxygenation-Stimulated Endothelial Cells via Nuclear Factor-kappa B-Dependent Pathway
J. Pharmacol. Exp. Ther., September 1, 2000; 294(3): 864 - 869.
[Abstract] [Full Text]


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Pharmacol. Rev.Home page
J. G. Wagner and R. A. Roth
Neutrophil Migration Mechanisms, with an Emphasis on the Pulmonary Vasculature
Pharmacol. Rev., September 1, 2000; 52(3): 349 - 374.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
B. S. Edwards, M. S. Curry, H. Tsuji, D. Brown, R. S. Larson, and L. A. Sklar
Expression of P-Selectin at Low Site Density Promotes Selective Attachment of Eosinophils Over Neutrophils
J. Immunol., July 1, 2000; 165(1): 404 - 410.
[Abstract] [Full Text] [PDF]


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Eur Heart JHome page
E Sbarouni, C Kroupis, Z.S Kyriakides, K Koniavitou, and D.T Kremastinos
Cell adhesion molecules in relation to simvastatin and hormone replacement therapy in coronary artery disease
Eur. Heart J., June 2, 2000; 21(12): 975 - 980.
[Abstract] [PDF]


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Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. M. Grunstein, H. Hakonarson, N. Maskeri, C. Kim, and S. Chuang
Intrinsic ICAM-1/LFA-1 activation mediates altered responsiveness of atopic asthmatic airway smooth muscle
Am J Physiol Lung Cell Mol Physiol, June 1, 2000; 278(6): L1154 - L1163.
[Abstract] [Full Text] [PDF]


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J. Pharmacol. Exp. Ther.Home page
S. P. Khor, K. McCarthy, M. DuPont, K. Murray, and G. Timony
Pharmacokinetics, Pharmacodynamics, Allometry, and Dose Selection of rPSGL-Ig for Phase I Trial
J. Pharmacol. Exp. Ther., May 1, 2000; 293(2): 618 - 624.
[Abstract] [Full Text]


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Ann. Thorac. Surg.Home page
G. Asimakopoulos, A. Kohn, D. C. Stefanou, D. O. Haskard, R. C. Landis, and K. M. Taylor
Leukocyte integrin expression in patients undergoing cardiopulmonary bypass
Ann. Thorac. Surg., April 1, 2000; 69(4): 1192 - 1197.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Heart Circ. Physiol.Home page
L. Ostrovsky, J. Carvalho-Tavares, R. C. Woodman, and P. Kubes
Translational inhibition of E-selectin expression stimulates P-selectin-dependent neutrophil recruitment
Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1225 - H1232.
[Abstract] [Full Text] [PDF]


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Int ImmunolHome page
U. Birner, T. B. Issekutz, U. Walter, and A. C. Issekutz
The role of {alpha}4 and LFA-1 integrins in selectin-independent monocyte and neutrophil migration to joints of rats with adjuvant arthritis
Int. Immunol., February 1, 2000; 12(2): 141 - 150.
[Abstract] [Full Text] [PDF]


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Arterioscler. Thromb. Vasc. Bio.Home page
M. Roque, J. T. Fallon, J. J. Badimon, W. X. Zhang, M. B. Taubman, and E. D. Reis
Mouse Model of Femoral Artery Denudation Injury Associated With the Rapid Accumulation of Adhesion Molecules on the Luminal Surface and Recruitment of Neutrophils
Arterioscler Thromb Vasc Biol, February 1, 2000; 20(2): 335 - 342.
[Abstract] [Full Text] [PDF]


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Antimicrob. Agents Chemother.Home page
P. van Langevelde, E. Ravensbergen, P. Grashoff, H. Beekhuizen, P. H. P. Groeneveld, and J. T. van Dissel
Antibiotic-Induced Cell Wall Fragments of Staphylococcus aureus Increase Endothelial Chemokine Secretion and Adhesiveness for Granulocytes
Antimicrob. Agents Chemother., December 1, 1999; 43(12): 2984 - 2989.
[Abstract] [Full Text]


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J. Immunol.Home page
K. Blease, Y. Chen, P. G. Hellewell, and A. Burke-Gaffney
Lipoteichoic Acid inhibits Lipopolysaccharide-Induced Adhesion Molecule Expression and IL-8 Release in Human Lung Microvascular Endothelial Cells
J. Immunol., December 1, 1999; 163(11): 6139 - 6147.
[Abstract] [Full Text] [PDF]


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J. Thorac. Cardiovasc. Surg.Home page
M. K. Ilton, P. E. Langton, M. L. Taylor, N. L. A. Misso, M. Newman, P. J. Thompson, and J. Hung
DIFFERENTIAL EXPRESSION OF NEUTROPHIL ADHESION MOLECULES DURING CORONARY ARTERY SURGERY WITH CARDIOPULMONARY BYPASS
J. Thorac. Cardiovasc. Surg., November 1, 1999; 118(5): 930 - 937.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
A. M. Lefer
Role of the {beta}2-integrins and immunoglobulin superfamily members in myocardial ischemia-reperfusion
Ann. Thorac. Surg., November 1, 1999; 68(5): 1920 - 1923.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
J. Gainet, P. M. C. Dang, S. Chollet-Martin, M. Brion, M. Sixou, J. Hakim, M.-A. Gougerot-Pocidalo, and C. Elbim
Neutrophil Dysfunctions, IL-8, and Soluble L-Selectin Plasma Levels in Rapidly Progressive Versus Adult and Localized Juvenile Periodontitis: Variations According to Disease Severity and Microbial Flora
J. Immunol., November 1, 1999; 163(9): 5013 - 5019.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
G. Asimakopoulos, P. L.C. Smith, C. P. Ratnatunga, and K. M. Taylor
Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass
Ann. Thorac. Surg., September 1, 1999; 68(3): 1107 - 1115.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Cell Physiol.Home page
H. Kobuchi, S. Roy, C. K. Sen, H. G. Nguyen, and L. Packer
Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway
Am J Physiol Cell Physiol, September 1, 1999; 277(3): C403 - C411.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Kamochi, F. Kamochi, Y. B. Kim, S. Sawh, J. M. Sanders, I. Sarembock, S. Green, J. S. Young, K. Ley, S. M. Fu, et al.
P-selectin and ICAM-1 mediate endotoxin-induced neutrophil recruitment and injury to the lung and liver
Am J Physiol Lung Cell Mol Physiol, August 1, 1999; 277(2): L310 - L319.
[Abstract] [Full Text] [PDF]


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J. Appl. Physiol.Home page
F. Zeni, C. Parent, R. Correa, C. Natanson, B. Freeman, J. Fontana, M. Quezado, R. L. Danner, Y. Fitz, S. Richmond, et al.
ICAM-1 and CD11b inhibition worsen outcome in rats with E. coli pneumonia
J Appl Physiol, July 1, 1999; 87(1): 299 - 307.
[Abstract] [Full Text] [PDF]


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PerfusionHome page
G. Asimakopoulos
Mechanisms of the systemic inflammatory response
Perfusion, July 1, 1999; 14(4): 269 - 277.
[PDF]


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ChestHome page
G. P. Downey, Q. Dong, J. Kruger, S. Dedhar, and V. Cherapanov
Regulation of Neutrophil Activation in Acute Lung Injury
Chest, July 1, 1999; 116 (2009): 46S - 54S.
[Full Text]


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Circ. Res.Home page
B. Y. Poon, C. A. Ward, W. R. Giles, and P. Kubes
Emigrated Neutrophils Regulate Ventricular Contractility via {alpha}4 Integrin
Circ. Res., June 11, 1999; 84(11): 1245 - 1251.
[Abstract] [Full Text] [PDF]


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Arch SurgHome page
P. A. Ward and A. B. Lentsch
The Acute Inflammatory Response and Its Regulation
Arch Surg, June 1, 1999; 134(6): 666 - 669.
[Abstract] [Full Text] [PDF]


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CirculationHome page
J. Reckless, E. M. Rubin, J. B. Verstuyft, J. C. Metcalfe, and D. J. Grainger
Monocyte Chemoattractant Protein-1 but Not Tumor Necrosis Factor-{alpha} Is Correlated With Monocyte Infiltration in Mouse Lipid Lesions
Circulation, May 4, 1999; 99(17): 2310 - 2316.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
M. Chello, P. Mastroroberto, E. Malta, F. Cirillo, and V. Celi
Inhibition by dipyridamole of neutrophil adhesion to vascular endothelium during coronary bypass surgery
Ann. Thorac. Surg., May 1, 1999; 67(5): 1277 - 1282.
[Abstract] [Full Text] [PDF]


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Am. J. Respir. Crit. Care Med.Home page
W. KARZAI, B. U. von SPECHT, C. PARENT, J. HABERSTROH, K. WOLLERSEN, C. NATANSON, S. M. BANKS, and PETER. Q. EICHACKER
G-CSF during Escherichia coli versus Staphylococcus aureus Pneumonia in Rats Has Fundamentally Different and Opposite Effects
Am. J. Respir. Crit. Care Med., May 1, 1999; 159(5): 1377 - 1382.
[Abstract] [Full Text] [PDF]


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Arch OphthalmolHome page
J. M. Yanni, L. K. Weimer, N. A. Sharif, S. X. Xu, D. A. Gamache, and J. M. Spellman
Inhibition of Histamine-Induced Human Conjunctival Epithelial Cell Responses by Ocular Allergy Drugs
Arch Ophthalmol, May 1, 1999; 117(5): 643 - 647.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
M. Krull, A. C. Klucken, F. N. Wuppermann, O. Fuhrmann, C. Magerl, J. Seybold, S. Hippenstiel, J. H. Hegemann, C. A. Jantos, and N. Suttorp
Signal Transduction Pathways Activated in Endothelial Cells Following Infection with Chlamydia pneumoniae
J. Immunol., April 15, 1999; 162(8): 4834 - 4841.
[Abstract] [Full Text] [PDF]


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J. Appl. Physiol.Home page
H. Sakurai, F. C. Schmalstieg, L. D. Traber, H. K. Hawkins, and D. L. Traber
Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep
J Appl Physiol, April 1, 1999; 86(4): 1151 - 1159.
[Abstract] [Full Text] [PDF]


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Am. J. Respir. Crit. Care Med.Home page
W. M. ABRAHAM, A. AHMED, J. R. SABATER, I. T. LAUREDO, Y. BOTVINNIKOVA, R. J. BJERCKE, X. HU, B. M. REVELLE, T. P. KOGAN, I. L. SCOTT, et al.
Selectin Blockade Prevents Antigen-induced Late Bronchial Responses and Airway Hyperresponsiveness in Allergic Sheep
Am. J. Respir. Crit. Care Med., April 1, 1999; 159(4): 1205 - 1214.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
Q. Dong, K. A. Siminovitch, L. Fialkow, T. Fukushima, and G. P. Downey
Negative Regulation of Myeloid Cell Proliferation and Function by the SH2 Domain-Containing Tyrosine Phosphatase-1
J. Immunol., March 15, 1999; 162(6): 3220 - 3230.
[Abstract] [Full Text] [PDF]


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Am. J. Respir. Crit. Care Med.Home page
S. SALVI, A. BLOMBERG, B. RUDELL, F. KELLY, T. SANDSTRÖM, S. T. HOLGATE, and A. FREW
Acute Inflammatory Responses in the Airways and Peripheral Blood After Short-Term Exposure to Diesel Exhaust in Healthy Human Volunteers
Am. J. Respir. Crit. Care Med., March 1, 1999; 159(3): 702 - 709.
[Abstract] [Full Text]


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J. Immunol.Home page
A. Mocsai, E. Ligeti, C. A. Lowell, and G. Berton
Adhesion-Dependent Degranulation of Neutrophils Requires the Src Family Kinases Fgr and Hck
J. Immunol., January 15, 1999; 162(2): 1120 - 1126.
[Abstract] [Full Text] [PDF]




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