FASEB J. DevicePharm for MP Biomedical
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dinarello, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dinarello, C. A.

The FASEB Journal, Vol 8, 1314-1325, Copyright © 1994 by The Federation of American Societies for Experimental Biology

REVIEWS

The interleukin-1 family: 10 years of discovery

CA Dinarello
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts.

Ten years ago the cloning of two interleukin-1 molecules (IL-1 alpha and IL-1 beta) resolved the question of whether a single polypeptide could evoke a wide variety of biological effects. During the past decade, the biology of IL-1 has greatly expanded our understanding of how the host responds to external challenges, such as injury and infection, as well as its role in several diseases. We learned of the remarkable potency of IL-1 in the femtomolar range and of its ability to induce a response by triggering only one or two receptors per cell. Unexpectedly, the IL-1 family of genes, receptors and associated molecules have been linked to those of Drosophila, nematodes, and microorganisms and IL-1 signal transduction is similar to that observed after cellular stress. The cloning of IL-1 opened other avenues of fundamental biological interest. For example, in addition to the two agonist molecules IL-1 alpha and IL-1 beta, a third member of the IL-1 gene family is a specific, high affinity receptor antagonist (IL-1 receptor antagonist). That this third member of the IL-1 family inhibits the other two is characteristic of the tight control over production and activity exerted on IL-1. Although IL-1 contributes to the pathogenesis of many diseases, a small amount appears to be needed to combat infection and initiate healing processes. This article highlights 10 years of discoveries on IL-1.


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
J. Sharma, Q. Li, B. B. Mishra, M. J. Georges, and J. M. Teale
Vaccination with an Attenuated Strain of Francisella novicida Prevents T-Cell Depletion and Protects Mice Infected with the Wild-Type Strain from Severe Sepsis
Infect. Immun., October 1, 2009; 77(10): 4314 - 4326.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. L. Hailey, S. Li, M. D. Andersen, M. Roy, V. L. Woods Jr, and P. A. Jennings
Pro-interleukin (IL)-1{beta} Shares a Core Region of Stability as Compared with Mature IL-1{beta} While Maintaining a Distinctly Different Configurational Landscape: A COMPARATIVE HYDROGEN/DEUTERIUM EXCHANGE MASS SPECTROMETRY STUDY
J. Biol. Chem., September 18, 2009; 284(38): 26137 - 26148.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. A. Ehses, G. Lacraz, M.-H. Giroix, F. Schmidlin, J. Coulaud, N. Kassis, J.-C. Irminger, M. Kergoat, B. Portha, F. Homo-Delarche, et al.
IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
PNAS, August 18, 2009; 106(33): 13998 - 14003.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Ceppi, P. M. Pereira, I. Dunand-Sauthier, E. Barras, W. Reith, M. A. Santos, and P. Pierre
MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells
PNAS, February 24, 2009; 106(8): 2735 - 2740.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Boni-Schnetzler, J. Thorne, G. Parnaud, L. Marselli, J. A. Ehses, J. Kerr-Conte, F. Pattou, P. A. Halban, G. C. Weir, and M. Y. Donath
Increased Interleukin (IL)-1{beta} Messenger Ribonucleic Acid Expression in {beta}-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1{beta} in Human Islets by Glucose and Autostimulation
J. Clin. Endocrinol. Metab., October 1, 2008; 93(10): 4065 - 4074.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Al-Sadi, D. Ye, K. Dokladny, and T. Y. Ma
Mechanism of IL-1{beta}-Induced Increase in Intestinal Epithelial Tight Junction Permeability
J. Immunol., April 15, 2008; 180(8): 5653 - 5661.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
Y. Cao, S.-F. Jia, G. Chakravarty, B. de Crombrugghe, and E. S. Kleinerman
The Osterix Transcription Factor Down-Regulates Interleukin-1{alpha} Expression in Mouse Osteosarcoma Cells
Mol. Cancer Res., January 1, 2008; 6(1): 119 - 126.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Liu, F. Lu, G. Qin, S. M. Fernandes, J. Li, and A. E. Davis III
C1 Inhibitor-Mediated Protection from Sepsis
J. Immunol., September 15, 2007; 179(6): 3966 - 3972.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
M. Jylha, P. Paavilainen, T. Lehtimaki, S. Goebeler, P. J. Karhunen, A. Hervonen, and M. Hurme
Interleukin-1 Receptor Antagonist, Interleukin-6, and C-Reactive Protein as Predictors of Mortality in Nonagenarians: The Vitality 90+ Study
J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2007; 62(9): 1016 - 1021.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J.-Y. Lu, N. Sadri, and R. J. Schneider
Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs
Genes & Dev., November 15, 2006; 20(22): 3174 - 3184.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
P. T. Nowicki
IL-1beta alters hemodynamics in newborn intestine: role of endothelin
Am J Physiol Gastrointest Liver Physiol, September 1, 2006; 291(3): G404 - G413.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Ferrari, C. Pizzirani, E. Adinolfi, R. M. Lemoli, A. Curti, M. Idzko, E. Panther, and F. Di Virgilio
The P2X7 Receptor: A Key Player in IL-1 Processing and Release
J. Immunol., April 1, 2006; 176(7): 3877 - 3883.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Kong, S. A. Grando, and Y. C. Li
Regulation of IL-1 Family Cytokines IL-1{alpha}, IL-1 Receptor Antagonist, and IL-18 by 1,25-Dihydroxyvitamin D3 in Primary Keratinocytes
J. Immunol., March 15, 2006; 176(6): 3780 - 3787.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
G. R. Martin and J. L. Wallace
Gastrointestinal Inflammation: A Central Component of Mucosal Defense and Repair
Experimental Biology and Medicine, February 1, 2006; 231(2): 130 - 137.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. A. Hefler, C. Grimm, T. Lantzsch, D. Lampe, S. Leodolter, H. Koelbl, G. Heinze, A. Reinthaller, D. Tong-Cacsire, C. Tempfer, et al.
Interleukin-1 and Interleukin-6 Gene Polymorphisms and the Risk of Breast Cancer in Caucasian Women
Clin. Cancer Res., August 15, 2005; 11(16): 5718 - 5721.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
H. Liu, H. Hanawa, T. Yoshida, R. Elnaggar, M. Hayashi, R. Watanabe, K. Toba, K. Yoshida, H. Chang, Y. Okura, et al.
Effect of Hydrodynamics-Based Gene Delivery of Plasmid DNA Encoding Interleukin-1 Receptor Antagonist-Ig for Treatment of Rat Autoimmune Myocarditis: Possible Mechanism for Lymphocytes and Noncardiac Cells
Circulation, April 5, 2005; 111(13): 1593 - 1600.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. G. Jeschke, D. Klein, U. Bolder, and R. Einspanier
Insulin Attenuates the Systemic Inflammatory Response in Endotoxemic Rats
Endocrinology, September 1, 2004; 145(9): 4084 - 4093.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. Nedrebo, R. K. Reed, R. Jonsson, A. Berg, and H. Wiig
Differential cytokine response in interstitial fluid in skin and serum during experimental inflammation in rats
J. Physiol., April 1, 2004; 556(1): 193 - 202.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Zhao and R. D. Brinton
Suppression of Proinflammatory Cytokines Interleukin-1{beta} and Tumor Necrosis Factor-{alpha} in Astrocytes by a V1 Vasopressin Receptor Agonist: A cAMP Response Element-Binding Protein-Dependent Mechanism
J. Neurosci., March 3, 2004; 24(9): 2226 - 2235.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Yang, M. Ochani, J. Li, X. Qiang, M. Tanovic, H. E. Harris, S. M. Susarla, L. Ulloa, H. Wang, R. DiRaimo, et al.
Reversing established sepsis with antagonists of endogenous high-mobility group box 1
PNAS, January 6, 2004; 101(1): 296 - 301.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
E. L. Oleszak, J. R. Chang, H. Friedman, C. D. Katsetos, and C. D. Platsoucas
Theiler's Virus Infection: a Model for Multiple Sclerosis
Clin. Microbiol. Rev., January 1, 2004; 17(1): 174 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
C. J. Czura, S. G. Friedman, and K. J. Tracey
Neural inhibition of inflammation: the cholinergic anti-inflammatory pathway
Innate Immunity, December 1, 2003; 9(6): 409 - 413.
[Abstract] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
J. Sehouli, A. Mustea, D. Koensgen, and W. Lichtenegger
Interleukin-1 Receptor Antagonist Gene Polymorphism in Epithelial Ovarian Cancer
Cancer Epidemiol. Biomarkers Prev., November 1, 2003; 12(11): 1205 - 1208.
[Abstract] [Full Text]

Home page
 Clin. Cancer Res.Home page
C. F. Singer, N. Kronsteiner, G. Hudelist, E. Marton, I. Walter, M. Kubista, K. Czerwenka, M. Schreiber, M. Seifert, and E. Kubista
Interleukin 1 System and Sex Steroid Receptor Expression in Human Breast Cancer: Interleukin 1{alpha} Protein Secretion Is Correlated with Malignant Phenotype
Clin. Cancer Res., October 15, 2003; 9(13): 4877 - 4883.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
J. Sehouli, A. Mustea, D. Koensgen, F. C.-K. Chen, and W. Lichtenegger
Interleukin-1 receptor antagonist gene polymorphism is associated with increased risk of epithelial ovarian cancer
Ann. Onc., October 1, 2003; 14(10): 1501 - 1504.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
B. Beutler, K. Hoebe, X. Du, and R. J. Ulevitch
How we detect microbes and respond to them: the Toll-like receptors and their transducers
J. Leukoc. Biol., October 1, 2003; 74(4): 479 - 485.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Kumar and R. S. Bahn
Relative Overexpression of Macrophage-Derived Cytokines in Orbital Adipose Tissue from Patients with Graves' Ophthalmopathy
J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4246 - 4250.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. J. Liu and R. H. Kennedy
Positive inotropic effect of ceramide in adult ventricular myocytes: mechanisms dissociated from its reduction in Ca2+ influx
Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H735 - H744.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. Mandinova, R. Soldi, I. Graziani, C. Bagala, S. Bellum, M. Landriscina, F. Tarantini, I. Prudovsky, and T. Maciag
S100A13 mediates the copper-dependent stress-induced release of IL-1{alpha} from both human U937 and murine NIH 3T3 cells
J. Cell Sci., July 1, 2003; 116(13): 2687 - 2696.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. E Desson and A. V. Ferguson
Interleukin 1{beta} modulates rat subfornical organ neurons as a result of activation of a non-selective cationic conductance
J. Physiol., July 1, 2003; 550(1): 113 - 122.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. Martoriati, G. Duchamp, and N. Gerard
In Vivo Effect of Epidermal Growth Factor, Interleukin-1{beta}, and Interleukin-1RA on Equine Preovulatory Follicles
Biol Reprod, May 1, 2003; 68(5): 1748 - 1754.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
F. Wieser, L. Hefler, C. Tempfer, U. Vlach, C. Schneeberger, J. Huber, and R. Wenzl
Polymorphism of the Interleukin-1{beta} Gene and Endometriosis
Reproductive Sciences, April 1, 2003; 10(3): 172 - 175.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
D. Brough, R. A. Le Feuvre, R. D. Wheeler, N. Solovyova, S. Hilfiker, N. J. Rothwell, and A. Verkhratsky
Ca2+ Stores and Ca2+ Entry Differentially Contribute to the Release of IL-1{beta} and IL-1{alpha} from Murine Macrophages
J. Immunol., March 15, 2003; 170(6): 3029 - 3036.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
L. A. Hefler, E. Ludwig, A. Lebrecht, R. Zeillinger, D. Tong-Cacsire, H. Koelbl, S. Leodolter, and C. B. Tempfer
Polymorphisms of the Interleukin-1 Gene Cluster and Ovarian Cancer
Reproductive Sciences, November 1, 2002; 9(6): 386 - 390.
[Abstract] [PDF]

Home page
 Drug Metab. Dispos.Home page
L. Romero, M. A. Higgins, J. Gilmore, K. Boudreau, A. Maslen, H. J. Barker, and G. M. Kirby
Down-Regulation of Alpha Class Glutathione S-Transferase by Interleukin-1beta in Human Intestinal Epithelial Cells (Caco-2) in Culture
Drug Metab. Dispos., November 1, 2002; 30(11): 1186 - 1193.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
N E Lane and Q Rehman
Osteoporosis in the rheumatic disease patient
Lupus, October 1, 2002; 11(10): 675 - 679.
[Abstract] [PDF]

Home page
 Biol. Reprod.Home page
A. Martoriati, A.-C. Lalmanach, G. Goudet, and N. Gerard
Expression of Interleukin-1 (IL-1) System Genes in Equine Cumulus-Oocyte Complexes and Influence of IL-1{beta} During In Vitro Maturation
Biol Reprod, August 1, 2002; 67(2): 630 - 636.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. Nakamura, Y. Kadono, H. Takayanagi, E. Jimi, T. Miyazaki, H. Oda, K. Nakamura, S. Tanaka, G. A. Rodan, and L. T. Duong
IL-1 Regulates Cytoskeletal Organization in Osteoclasts Via TNF Receptor-Associated Factor 6/c-Src Complex
J. Immunol., May 15, 2002; 168(10): 5103 - 5109.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Toda, J. Tsukada, M. Misago, Y. Kominato, P. E. Auron, and Y. Tanaka
Autocrine Induction of the Human Pro-IL-1{beta} Gene Promoter by IL-1{beta} in Monocytes
J. Immunol., February 15, 2002; 168(4): 1984 - 1991.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
J. L. Wallace and L. Ma
Inflammatory Mediators in Gastrointestinal Defense and Injury
Experimental Biology and Medicine, December 1, 2001; 226(11): 1003 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
A.-M. Bleau, C. Fradette, A. O. S. El-Kadi, M.-C. Cote, and P. du Souich
Cytochrome P450 Down-Regulation by Serum from Humans with a Viral Infection and from Rabbits with an Inflammatory Reaction
Drug Metab. Dispos., July 1, 2001; 29(7): 1007 - 1012.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. La and S. M. Fischer
Transcriptional Regulation of Intracellular IL-1 Receptor Antagonist Gene by IL-1{{alpha}} in Primary Mouse Keratinocytes
J. Immunol., May 15, 2001; 166(10): 6149 - 6155.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
E. H.S. Choy and G. S. Panayi
Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis
N. Engl. J. Med., March 22, 2001; 344(12): 907 - 916.
[Full Text] [PDF]

Home page
 IOVSHome page
C. L. Cubitt, R. N. Lausch, and J. E. Oakes
Synthesis of Type II Interleukin-1 Receptors by Human Corneal Epithelial Cells but not by Keratocytes
Invest. Ophthalmol. Vis. Sci., March 1, 2001; 42(3): 701 - 704.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. A. Melendez, J. M. Vinci, J. J. Jeffrey, and B. D. Wilcox
Localization and regulation of IL-1{alpha} in rat myometrium during late pregnancy and the postpartum period
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2001; 280(3): R879 - R888.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Z. Zhang and G. M. Fuller
Interleukin 1beta inhibits interleukin 6-mediated rat gamma fibrinogen gene expression
Blood, November 15, 2000; 96(10): 3466 - 3472.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. J. Lee, K. Drabik, N. J. Van Wagoner, S. Lee, C. Choi, Y. Dong, and E. N. Benveniste
ICAM-1-Induced Expression of Proinflammatory Cytokines in Astrocytes: Involvement of Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways
J. Immunol., October 15, 2000; 165(8): 4658 - 4666.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Hou, S. Moller, L. Edvinsson, and D. Erlinge
Cytokines Induce Upregulation of Vascular P2Y2 Receptors and Increased Mitogenic Responses to UTP and ATP
Arterioscler Thromb Vasc Biol, September 1, 2000; 20(9): 2064 - 2069.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. Solomon, M. Rosenblatt, D.-Q. Li, Z. Liu, D. Monroy, Z. Ji, B. L. Lokeshwar, and S. C. Pflugfelder
Doxycycline Inhibition of Interleukin-1 in the Corneal Epithelium
Invest. Ophthalmol. Vis. Sci., August 1, 2000; 41(9): 2544 - 2557.
[Abstract] [Full Text]

Home page
 Am. J. Clin. Nutr.Home page
R. J Playford, C. E Macdonald, and W. S Johnson
Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders
Am. J. Clinical Nutrition, July 1, 2000; 72(1): 5 - 14.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Kumar, P. C. McDonnell, R. Lehr, L. Tierney, M. N. Tzimas, D. E. Griswold, E. A. Capper, R. Tal-Singer, G. I. Wells, M. L. Doyle, et al.
Identification and Initial Characterization of Four Novel Members of the Interleukin-1 Family
J. Biol. Chem., March 31, 2000; 275(14): 10308 - 10314.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. J. Feldman, L. Aguirre, M. Ziol, J.-P. Bridou, N. Nevo, J.-B. Michel, and P. G. Steg
Interleukin-10 Inhibits Intimal Hyperplasia After Angioplasty or Stent Implantation in Hypercholesterolemic Rabbits
Circulation, February 29, 2000; 101(8): 908 - 916.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Azuma, K. Kaji, R. Katogi, S. Takeshita, and A. Kudo
Tumor Necrosis Factor-alpha Induces Differentiation of and Bone Resorption by Osteoclasts
J. Biol. Chem., February 18, 2000; 275(7): 4858 - 4864.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Hasko, D. G. Kuhel, Z. H. Nemeth, J. G. Mabley, R. F. Stachlewitz, L. Virag, Z. Lohinai, G. J. Southan, A. L. Salzman, and C. Szabo
Inosine Inhibits Inflammatory Cytokine Production by a Posttranscriptional Mechanism and Protects Against Endotoxin-Induced Shock
J. Immunol., January 15, 2000; 164(2): 1013 - 1019.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Cambien, M.-A. Millet, H. Schmid-Antomarchi, N. Brossette, B. Rossi, and A. Schmid-Alliana
Src-Regulated Extracellular Signal-Related Kinase and Syk-Regulated c-Jun N-Terminal Kinase Pathways Act in Conjunction to Induce IL-1 Synthesis in Response to Microtubule Disruption in HL60 Cells
J. Immunol., November 1, 1999; 163(9): 5079 - 5085.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Vinals, J. Martinez-Gonzalez, and L. Badimon
Regulatory Effects of HDL on Smooth Muscle Cell Prostacyclin Release
Arterioscler Thromb Vasc Biol, October 1, 1999; 19(10): 2405 - 2411.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. C. Higgins, Y. Wu, and A. E. Postlethwaite
Intracellular IL-1 Receptor Antagonist Is Elevated in Human Dermal Fibroblasts That Overexpress Intracellular Precursor IL-1{alpha}
J. Immunol., October 1, 1999; 163(7): 3969 - 3975.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
H. Wang, O. Bloom, M. Zhang, J. M. Vishnubhakat, M. Ombrellino, J. Che, A. Frazier, H. Yang, S. Ivanova, L. Borovikova, et al.
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Science, July 9, 1999; 285(5425): 248 - 251.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
R. F. Lodato, A. R. Khan, M. J. Zembowicz, N. W. Weisbrodt, T. A. Pressley, Y.-F. Li, J. A. Lodato, A. Zembowicz, and F. G. Moody
Roles of IL-1 and TNF in the decreased ileal muscle contractility induced by lipopolysaccharide
Am J Physiol Gastrointest Liver Physiol, June 1, 1999; 276(6): G1356 - G1362.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. P. Luk, Y. Zhang, T. D. White, F. A. Lue, C. Wu, C.-G. Jiang, L. Zhang, and H. Moldofsky
Adenosine: a Mediator of Interleukin-1beta -Induced Hippocampal Synaptic Inhibition
J. Neurosci., June 1, 1999; 19(11): 4238 - 4244.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
V. Baud, Z.-G. Liu, B. Bennett, N. Suzuki, Y. Xia, and M. Karin
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain
Genes & Dev., May 15, 1999; 13(10): 1297 - 1308.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
H. F. Staats and F. A. Ennis Jr.
IL-1 Is an Effective Adjuvant for Mucosal and Systemic Immune Responses When Coadministered with Protein Immunogens
J. Immunol., May 15, 1999; 162(10): 6141 - 6147.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
M. Kobayashi, N. Okada, Y. Okamatsu, K. Mugikura, T. Nishihara, S. Hanazawa, S. Kitano, and K. Hasegawa
Intracellular Interleukin-1{alpha} Production in Human Gingival Fibroblasts is Differentially Regulated by Various Cytokines
Journal of Dental Research, April 1, 1999; 78(4): 840 - 849.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
J. W. Zumwalt, B. J. Thunstrom, and B. L. Spangelo
Interleukin-1{beta} and Catecholamines Synergistically Stimulate Interleukin-6 Release from Rat C6 Glioma Cells in Vitro: a Potential Role for Lysophosphatidylcholine
Endocrinology, February 1, 1999; 140(2): 888 - 896.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
W. Rohn, L. P. Tang, Y. Dong, and E. N. Benveniste
IL-1{beta} Inhibits IFN-{gamma}-Induced Class II MHC Expression by Suppressing Transcription of the Class II Transactivator Gene
J. Immunol., January 15, 1999; 162(2): 886 - 896.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Han, T. Meng, N. R. Murray, A. P. Fields, and A. R. Brasier
Interleukin-1-induced Nuclear Factor-kappa B-Ikappa Balpha Autoregulatory Feedback Loop in Hepatocytes. A ROLE FOR PROTEIN KINASE Calpha IN POST-TRANSCRIPTIONAL REGULATION OF Ikappa Balpha RESYNTHESIS
J. Biol. Chem., January 8, 1999; 274(2): 939 - 947.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A Bavelloni, S Santi, A Sirri, M Riccio, I Faenza, N Zini, S Cecchi, A Ferri, P Auron, N. Maraldi, et al.
Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells
J. Cell Sci., January 3, 1999; 112(5): 631 - 640.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
O. V. Kolomytkin, A. A. Marino, K. K. Sadasivan, R. E. Wolf, and J. A. Albright
Intracellular signaling mechanisms of interleukin-1beta in synovial fibroblasts
Am J Physiol Cell Physiol, January 1, 1999; 276(1): C9 - C15.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
F.F. Paula-Lopes, A.A.S. de Moraes, J.L. Edwards, J.E. Justice, and P.J. Hansen
Regulation of Preimplantation Development of Bovine Embryos by Interleukin-1ß
Biol Reprod, December 1, 1998; 59(6): 1406 - 1412.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Schenker
Respiratory Health Hazards in Agriculture
Am. J. Respir. Crit. Care Med., November 1, 1998; 158(2007): S1 - S76.
[Full Text] [PDF]

Home page
 Arch Intern MedHome page
P. A. Mackowiak
Concepts of Fever
Arch Intern Med, September 28, 1998; 158(17): 1870 - 1881.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
J. Dumin, B. D. Wilcox, I. Otterness, J. A. Melendez, C. Huang, and J. J. Jeffrey
Serotonin-mediated Production of Interstitial Collagenase by Uterine Smooth Muscle Cells Requires Interleukin-1alpha , but not Interleukin-1beta
J. Biol. Chem., September 25, 1998; 273(39): 25488 - 25494.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. S. H. Liu, T. D. Amaral, C. F. Brosnan, and S. C. Lee
IFNs Are Critical Regulators of IL-1 Receptor Antagonist and IL-1 Expression in Human Microglia
J. Immunol., August 15, 1998; 161(4): 1989 - 1996.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. Meinhardt, M. Bacher, C. Metz, R. Bucala, N. Wreford, H. Lan, R. Atkins, and M. Hedger
Local Regulation of Macrophage Subsets in the Adult Rat Testis: Examination of the Roles of the Seminiferous Tubules, Testosterone, and Macrophage-Migration Inhibitory Factor
Biol Reprod, August 1, 1998; 59(2): 371 - 378.
[Abstract] [Full Text]

Home page
 Antimicrob. Agents Chemother.Home page
A. A. Khan, T. R. Slifer, and J. S. Remington
Effect of Trovafloxacin on Production of Cytokines by Human Monocytes
Antimicrob. Agents Chemother., July 1, 1998; 42(7): 1713 - 1717.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
A. Kumar, A. Middleton, T. C. Chambers, and K. D. Mehta
Differential Roles of Extracellular Signal-regulated Kinase-1/2 and p38MAPK in Interleukin-1beta - and Tumor Necrosis Factor-alpha -induced Low Density Lipoprotein Receptor Expression in HepG2 Cells
J. Biol. Chem., June 19, 1998; 273(25): 15742 - 15748.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. M. Chaudhary, C. Ferguson, V. Nguyen, O. Nguyen, H. F. Massa, M. Eby, A. Jasmin, B. J. Trask, L. Hood, and P. S. Nelson
Cloning and Characterization of Two Toll/Interleukin-1 Receptor-Like Genes TIL3 and TIL4: Evidence for a Multi-Gene Receptor Family in Humans
Blood, June 1, 1998; 91(11): 4020 - 4027.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. Roth, D. Martin, B. Storr, and E. Zeisberger
Neutralization of pyrogen-induced tumour necrosis factor by its type 1 soluble receptor in guinea-pigs: effects on fever and interleukin-6 release
J. Physiol., May 15, 1998; 509(1): 267 - 275.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
E M Nilsen, F-E Johansen, F L Jahnsen, K E A Lundin, T Scholz, P Brandtzaeg, and G Haraldsen
Cytokine profiles of cultured microvascular endothelial cells from the human intestine
Gut, May 1, 1998; 42(5): 635 - 642.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Jimi, I. Nakamura, T. Ikebe, S. Akiyama, N. Takahashi, and T. Suda
Activation of NF-kappa B Is Involved in the Survival of Osteoclasts Promoted by Interleukin-1
J. Biol. Chem., April 10, 1998; 273(15): 8799 - 8805.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Z. Guan, S. Y. Buckman, L. D. Baier, and A. R. Morrison
IGF-I and insulin amplify IL-1beta -induced nitric oxide and prostaglandin biosynthesis
Am J Physiol Renal Physiol, April 1, 1998; 274(4): F673 - F679.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Y. C. Lo, L. Luo, C. A. G. McCulloch, and T. F. Cruz
Requirements of Focal Adhesions and Calcium Fluxes for Interleukin-1-induced ERK Kinase Activation and c-fos Expression in Fibroblasts
J. Biol. Chem., March 20, 1998; 273(12): 7059 - 7065.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. R. Hill, G. Kwon, C. A. Marshall, and M. L. McDaniel
Hyperglycemic Levels of Glucose Inhibit Interleukin 1 Release from RAW 264.7 Murine Macrophages by Activation of Protein Kinase C
J. Biol. Chem., February 6, 1998; 273(6): 3308 - 3313.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
E. Roberts, K.A. McCaffery, and S.M. Michalek
Profile of Cytokine mRNA Expression in Chronic Adult Periodontitis
Journal of Dental Research, December 1, 1997; 76(12): 1833 - 1839.
[Abstract] [PDF]

Home page
 Am J Sports MedHome page
M. Cameron, A. Buchgraber, H. Passler, M. Vogt, E. Thonar, F. Fu, and C. H. Evans
The Natural History of the Anterior Cruciate Ligament-Deficient Knee: Changes in Synovial Fluid Cytokine and Keratan Sulfate Concentrations
Am. J. Sports Med., December 1, 1997; 25(6): 751 - 754.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
O. V. Kolomytkin, A. A. Marino, K. K. Sadasivan, R. E. Wolf, and J. A. Albright
Interleukin-1beta switches electrophysiological states of synovial fibroblasts
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1997; 273(5): R1822 - R1828.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Hofmeister, K. Wiegmann, C. Korherr, K. Bernardo, M. Kronke, and W. Falk
Activation of Acid Sphingomyelinase by Interleukin-1 (IL-1) Requires the IL-1 Receptor Accessory Protein
J. Biol. Chem., October 31, 1997; 272(44): 27730 - 27736.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Maheo, J. Antras-Ferry, F. Morel, S. Langouet, and A. Guillouzo
Modulation of Glutathione S-Transferase Subunits A2, M1, and P1 Expression by Interleukin-1beta in Rat Hepatocytes in Primary Culture
J. Biol. Chem., June 27, 1997; 272(26): 16125 - 16132.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. D. Finder, J. L. Litz, M. A. Blaskovich, T. F. McGuire, Y. Qian, A. D. Hamilton, P. Davies, and S. M. Sebti
Inhibition of Protein Geranylgeranylation Causes a Superinduction of Nitric-oxide Synthase-2 by Interleukin-1beta in Vascular Smooth Muscle Cells
J. Biol. Chem., May 23, 1997; 272(21): 13484 - 13488.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Stella, A. Estelles, J. Siciliano, M. Tence, S. Desagher, D. Piomelli, J. Glowinski, and J. Premont
Interleukin-1 Enhances the ATP-Evoked Release of Arachidonic Acid from Mouse Astrocytes
J. Neurosci., May 1, 1997; 17(9): 2939 - 2946.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Guan, L. D. Baier, and A. R. Morrison
p38 Mitogen-activated Protein Kinase Down-regulates Nitric Oxide and Up-regulates Prostaglandin E2 Biosynthesis Stimulated by Interleukin-1beta
J. Biol. Chem., March 21, 1997; 272(12): 8083 - 8089.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Yang, H. Hayashi, T. Takii, Y. Mizutani, Y. Inukai, and K. Onozaki
Interleukin-1-induced Growth Inhibition of Human Melanoma Cells. INTERLEUKIN-1-INDUCED ANTIZYME EXPRESSION IS RESPONSIBLE FOR ORNITHINE DECARBOXYLASE ACTIVITY DOWN-REGULATION
J. Biol. Chem., February 7, 1997; 272(6): 3376 - 3383.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F. T. Stevenson, J. Turck, R. M. Locksley, and D. H. Lovett
The N-terminal propiece of interleukin 1alpha is a transforming nuclear oncoprotein
PNAS, January 21, 1997; 94(2): 508 - 513.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
A. Havemose-Poulsen and P. Holmstrup
Factors Affecting IL-1-Mediated Collagen Metabolism By Fibroblasts and the Pathogenesis of Periodontal Disease: A Review of the Literature
Critical Reviews in Oral Biology & Medicine, January 1, 1997; 8(2): 217 - 236.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. L. Akeson, C. W. Woods, L. C. Hsieh, R. A. Bohnke, B. L. Ackermann, K. Y. Chan, J. L. Robinson, S. D. Yanofsky, J. W. Jacobs, R. W. Barrett, et al.
AF12198, a Novel Low Molecular Weight Antagonist, Selectively Binds the Human Type I Interleukin (IL)-1 Receptor and Blocks in Vivo Responses to IL-1
J. Biol. Chem., November 29, 1996; 271(48): 30517 - 30523.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. M. Cahill, W. R. Waterman, Y. Xie, P. E. Auron, and StuartK. Calderwood
Transcriptional repression of the prointerleukin 1beta gene by heat shock factor 1
J. Biol. Chem., October 4, 1996; 271(40): 24874 - 24879.
[Full Text]

Home page
 J. Biol. Chem.Home page
J. R. Hill, J. A. Corbett, G. Kwon, C. A. Marshall, and M. L. McDaniel
Nitric Oxide Regulates Interleukin 1Bioactivity Released from Murine Macrophages
J. Biol. Chem., September 13, 1996; 271(37): 22672 - 22678.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
X.-Y. Hua, P. Chen, A. Fox, and R. R. Myers
Involvement of Cytokines in Lipopolysaccharide-Induced Facilitation of CGRP Release from Capsaicin-Sensitive Nerves in the Trachea: Studies with Interleukin-1beta and Tumor Necrosis Factor-alpha
J. Neurosci., August 1, 1996; 16(15): 4742 - 4748.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Tetsuka, L. D. Baier, and A. R. Morrison
Antioxidants Inhibit Interleukin-1-induced Cyclooxygenase and Nitric-oxide Synthase Expression in Rat Mesangial Cells
J. Biol. Chem., May 17, 1996; 271(20): 11689 - 11693.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. L. Mitcham, P. Parnet, T. P. Bonnert, K. E. Garka, M. J. Gerhart, J. L. Slack, M. A. Gayle, S. K. Dower, and J. E. Sims
T1/ST2 Signaling Establishes It as a Member of an Expanding Interleukin-1 Receptor Family
J. Biol. Chem., March 8, 1996; 271(10): 5777 - 5783.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by The Federation of American Societies for Experimental Biology.