FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yuan, D.
Right arrow Articles by Wilder, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yuan, D.
Right arrow Articles by Wilder, J. A.

The FASEB Journal, Vol 8, 1012-1018, Copyright © 1994 by The Federation of American Societies for Experimental Biology

REVIEWS

Interactions between B lymphocytes and NK cells

D Yuan, CY Koh and JA Wilder
Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235.

The ability of natural killer (NK) cells to secrete lymphokines confers upon them the potential to regulate cell types via mechanisms other than direct cytotoxicity. During the past few years increasing evidence has been accumulating to show that NK and B cells can interact productively. First, NK cells cocultured with B cells can induce them to initiate polyclonal Ig secretion. This help is mediated by a soluble factor (or factors) that appears to be different from any known cytokine. Second, preactivated B lymphocytes can induce NK cells to produce greater amounts of IFN-gamma via an interaction that requires direct cell contact. Third, in contrast to previous suggestions, NK cells do not have the ability to kill primary B lymphocytes regardless of their stage of differentiation. Evaluation of the in vivo relevance of these interactions revealed that activated NK cells can increase the IgG2a response to a specific protein antigen. Without activation, NK cells neither enhance nor inhibit B cell responses to antigens. The deviation of the isotype distribution may allow increased NK cell specificity for certain pathogens by enhancing antibody-dependent cytotoxicity.


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
A.-H. Hovav, L. Davidovitch, G. Nussbaum, J. Mullerad, Y. Fishman, and H. Bercovier
Mitogenicity of the Recombinant Mycobacterial 27-Kilodalton Lipoprotein Is Not Connected to Its Antiprotective Effect
Infect. Immun., June 1, 2004; 72(6): 3383 - 3390.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. M. Orengo, E. Di Carlo, A. Comes, M. Fabbi, T. Piazza, M. Cilli, P. Musiani, and S. Ferrini
Tumor Cells Engineered with IL-12 and IL-15 Genes Induce Protective Antibody Responses in Nude Mice
J. Immunol., July 15, 2003; 171(2): 569 - 575.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. J. Loza, L. Zamai, L. Azzoni, E. Rosati, and B. Perussia
Expression of type 1 (interferon gamma) and type 2 (interleukin-13, interleukin-5) cytokines at distinct stages of natural killer cell differentiation from progenitor cells
Blood, February 15, 2002; 99(4): 1273 - 1281.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. R. Blanca, E. W. Bere, H. A. Young, and J. R. Ortaldo
Human B Cell Activation by Autologous NK Cells Is Regulated by CD40-CD40 Ligand Interaction: Role of Memory B Cells and CD5+ B Cells
J. Immunol., December 1, 2001; 167(11): 6132 - 6139.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Gao, T. Dang, and D. Yuan
IFN-{gamma}-Dependent and -Independent Initiation of Switch Recombination by NK Cells
J. Immunol., August 15, 2001; 167(4): 2011 - 2018.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
A. M. Harandi, B. Svennerholm, J. Holmgren, and K. Eriksson
Differential roles of B cells and IFN-{{gamma}}-secreting CD4+ T cells in innate and adaptive immune control of genital herpes simplex virus type 2 infection in mice
J. Gen. Virol., April 1, 2001; 82(4): 845 - 853.
[Abstract] [Full Text]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. K. Demetrikopoulos, R. H. Goldfarb, Z.-b. Zhang, and J. M. Weiss
Blood Level of B and CD4+ Lymphocytes Measured before Induction of an Experimental Tumor in Rats Predicts Tumor Progression and Survival
Cancer Epidemiol. Biomarkers Prev., June 1, 2000; 9(6): 609 - 617.
[Abstract] [Full Text]

Home page
 Infect. Immun.Home page
K. L. Elkins, C. M. Bosio, and T. R. Rhinehart-Jones
Importance of B cells, but Not Specific Antibodies, in Primary and Secondary Protective Immunity to the Intracellular Bacterium Francisella tularensis Live Vaccine Strain
Infect. Immun., November 1, 1999; 67(11): 6002 - 6007.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Quan, Z.-b. Zhang, M. K. Demetrikopoulos, R. P. Kitson, W. H. Chambers, R. H. Goldfarb, and J. M. Weiss
Evidence for Involvement of B Lymphocytes in the Surveillance of Lung Metastasis in the Rat
Cancer Res., March 1, 1999; 59(5): 1080 - 1089.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. Hoek, J. Schoemaker, and H. A. Drexhage
Premature Ovarian Failure and Ovarian Autoimmunity
Endocr. Rev., February 1, 1997; 18(1): 107 - 134.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by The Federation of American Societies for Experimental Biology.