FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jans, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jans, D. A.

The FASEB Journal, Vol 8, 841-847, Copyright © 1994 by The Federation of American Societies for Experimental Biology

REVIEWS

Nuclear signaling pathways for polypeptide ligands and their membrane receptors?

DA Jans
Division for Biochemistry and Molecular Biology, John Curtin School of Medical Research, Canberra, Australia.

Classical signal transduction theory revolves around the premise that the role of membrane receptors is to transfer the signal represented by ligand binding from the external cell surface across the membrane to within the cell. Other components of the signaling cascade such as second-messenger molecules and kinases then convey the signal from the cytoplasm to the nucleus to effect changes in gene expression. Membrane receptor endocytosis is seen as part of the cellular down-regulation and desensitization apparatus rather than as having an active signaling function. Evidence is mounting, however, that polypeptide ligands and their membrane receptors may have an important additional signaling role within the cell including the nucleus. Several ligands such as those of the platelet-derived and fibroblast growth factor classes have been found not only to localize in the nucleus, but also to possess sequences similar to the nuclear localization signal of the simian virus SV40 large T antigen. In most cases where they have been examined, these sequences appear to be both functional in nuclear targeting and essential for full signaling activity. The implication is that subsequent to internalization, polypeptide ligands and/or their receptors may translocate to the nucleus and participate directly in regulating gene expression.


This article has been cited by other articles:


Home page
 IOVSHome page
P. deS. Senanayake, J. Drazba, K. Shadrach, A. Milsted, E. Rungger-Brandle, K. Nishiyama, S.-I. Miura, S. Karnik, J. E. Sears, and J. G. Hollyfield
Angiotensin II and Its Receptor Subtypes in the Human Retina
Invest. Ophthalmol. Vis. Sci., July 1, 2007; 48(7): 3301 - 3311.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. Zhang, J. Kosman, N. Carmean, R. Grady, and J. A. Bassuk
FGF-10 and its receptor exhibit bidirectional paracrine targeting to urothelial and smooth muscle cells in the lower urinary tract
Am J Physiol Renal Physiol, August 1, 2006; 291(2): F481 - F494.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
T. Funasaka, T. Yanagawa, V. Hogan, and A. Raz
Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia
FASEB J, September 1, 2005; 19(11): 1422 - 1430.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
H. Nishimura, A. Fujimoto, N. Tamura, T. Yajima, W. Wajjwalku, and Y. Yoshikai
A novel autoregulatory mechanism for transcriptional activation of the IL-15 gene by a nonsecretable isoform of IL-15 generated by alternative splicing
FASEB J, January 1, 2005; 19(1): 19 - 28.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Polgar, G. Kispal, M. Lachmann, G. Paar, E. Nagy, P. Csere, E. Miko, L. Szereday, P. Varga, and J. Szekeres-Bartho
Molecular Cloning and Immunologic Characterization of a Novel cDNA Coding for Progesterone-Induced Blocking Factor
J. Immunol., December 1, 2003; 171(11): 5956 - 5963.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Fittipaldi, A. Ferrari, M. Zoppe, C. Arcangeli, V. Pellegrini, F. Beltram, and M. Giacca
Cell Membrane Lipid Rafts Mediate Caveolar Endocytosis of HIV-1 Tat Fusion Proteins
J. Biol. Chem., September 5, 2003; 278(36): 34141 - 34149.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. M. Fiaschi-Taesch and A. F. Stewart
Minireview: Parathyroid Hormone-Related Protein as an Intracrine Factor--Trafficking Mechanisms and Functional Consequences
Endocrinology, February 1, 2003; 144(2): 407 - 411.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. Olsnes, O. Klingenberg, and A. Wiedlocha
Transport of Exogenous Growth Factors and Cytokines to the Cytosol and to the Nucleus
Physiol Rev, January 1, 2003; 83(1): 163 - 182.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
B. Pan, K. Sengoku, K. Goishi, N. Takuma, T. Yamashita, K. Wada, and M. Ishikawa
The soluble and membrane-anchored forms of heparin-binding epidermal growth factor-like growth factor appear to play opposing roles in the survival and apoptosis of human luteinized granulosa cells
Mol. Hum. Reprod., August 1, 2002; 8(8): 734 - 741.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Kishima, H. Yamamoto, Y. Izumoto, K. Yoshida, H. Enomoto, M. Yamamoto, T. Kuroda, H. Ito, K. Yoshizaki, and H. Nakamura
Hepatoma-derived Growth Factor Stimulates Cell Growth after Translocation to the Nucleus by Nuclear Localization Signals
J. Biol. Chem., March 15, 2002; 277(12): 10315 - 10322.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Boudin, P. Sarret, J. Mazella, A. Schonbrunn, and A. Beaudet
Somatostatin-Induced Regulation of SST2A Receptor Expression and Cell Surface Availability in Central Neurons: Role of Receptor Internalization
J. Neurosci., August 15, 2000; 20(16): 5932 - 5939.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Tezel and M. B. Wax
The Mechanisms of hsp27 Antibody-Mediated Apoptosis in Retinal Neuronal Cells
J. Neurosci., May 15, 2000; 20(10): 3552 - 3562.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Dubois, F. Magrangeas, P. Lehours, S. Raher, J. Bernard, O. Boisteau, S. Leroy, S. Minvielle, A. Godard, and Y. Jacques
Natural Splicing of Exon 2 of Human Interleukin-15 Receptor alpha -Chain mRNA Results in a Shortened Form with a Distinct Pattern of Expression
J. Biol. Chem., September 17, 1999; 274(38): 26978 - 26984.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Sarret, D. Nouel, C. Dal Farra, J.-P. Vincent, A. Beaudet, and J. Mazella
Receptor-mediated Internalization Is Critical for the Inhibition of the Expression of Growth Hormone by Somatostatin in the Pituitary Cell Line AtT-20
J. Biol. Chem., July 2, 1999; 274(27): 19294 - 19300.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. H. C. Lam, C. M. House, T. Tiganis, K. I. Mitchelhill, B. Sarcevic, A. Cures, R. Ramsay, B. E. Kemp, T. J. Martin, and M. T. Gillespie
Phosphorylation at the Cyclin-dependent Kinases Site (Thr85) of Parathyroid Hormone-related Protein Negatively Regulates Its Nuclear Localization
J. Biol. Chem., June 25, 1999; 274(26): 18559 - 18566.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
M. Keresztes and J. Boonstra
Import(ance) of Growth Factors in(to) the Nucleus
J. Cell Biol., May 3, 1999; 145(3): 421 - 424.
[Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. Arese, Y. Chen, R. Z. Florkiewicz, A. Gualandris, B. Shen, and D. B. Rifkin
Nuclear Activities of Basic Fibroblast Growth Factor: Potentiation of Low-Serum Growth Mediated by Natural or Chimeric Nuclear Localization Signals
Mol. Biol. Cell, May 1, 1999; 10(5): 1429 - 1444.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
M. H. C. Lam, L. J. Briggs, W. Hu, T. J. Martin, M. T. Gillespie, and D. A. Jans
Importin beta  Recognizes Parathyroid Hormone-related Protein with High Affinity and Mediates Its Nuclear Import in the Absence of Importin alpha
J. Biol. Chem., March 12, 1999; 274(11): 7391 - 7398.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. S. Subramaniam, M. G. Mujtaba, M. R. Paddy, and H. M. Johnson
The Carboxyl Terminus of Interferon-gamma Contains a Functional Polybasic Nuclear Localization Sequence
J. Biol. Chem., January 1, 1999; 274(1): 403 - 407.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. G. Sabbieti, L. Marchetti, C. Abreu, A. Montero, A. R. Hand, L. G. Raisz, and M. M. Hurley
Prostaglandins Regulate the Expression of Fibroblast Growth Factor-2 in Bone
Endocrinology, January 1, 1999; 140(1): 434 - 444.
[Abstract] [Full Text]

Home page
 J. Cell Biol.Home page
T. Pederson
Growth Factors in the Nucleolus?
J. Cell Biol., October 19, 1998; 143(2): 279 - 281.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G.-f. Hu
Neomycin inhibits angiogenin-induced angiogenesis
PNAS, August 18, 1998; 95(17): 9791 - 9795.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. D. LeBoeuf, E. M. H. Ban, M. M. Green, A. S. Stone, S. M. Propst, J. E. Blalock, and J. D. Tauber
Molecular Cloning, Sequence Analysis, Expression, and Tissue Distribution of Suppressin, a Novel Suppressor of Cell Cycle Entry
J. Biol. Chem., January 2, 1998; 273(1): 361 - 368.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. A.E. Kruyt, Q. Waisfisz, L. M. Dijkmans, M. A.J.A. Hermsen, H. Youssoufian, F. Arwert, and H. Joenje
Cytoplasmic Localization of a Functionally Active Fanconi Anemia Group A-Green Fluorescent Protein Chimera in Human 293 Cells
Blood, November 1, 1997; 90(9): 3288 - 3295.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Yang, D. Lu, G. P. Vinson, and M. K. Raizada
Involvement of MAP Kinase in Angiotensin II-Induced Phosphorylation and Intracellular Targeting of Neuronal AT1 Receptors
J. Neurosci., March 1, 1997; 17(5): 1660 - 1669.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. A. Jans, P. Jans, L. J. Briggs, V. Sutton, and J. A. Trapani
Nuclear Transport of Granzyme B (Fragmentin-2). DEPENDENCE ON PERFORIN IN VIVO AND CYTOSOLIC FACTORS IN VITRO
J. Biol. Chem., November 29, 1996; 271(48): 30781 - 30789.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
B. Erdmann, K. Fuxe, and D. Ganten
Subcellular Localization of Angiotensin II Immunoreactivity in the Rat Cerebellar Cortex
Hypertension, November 1, 1996; 28(5): 818 - 824.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
H. Bonnet, O. Filhol, I. Truchet, P. Brethenou, C. Cochet, F. Amalric, and G. Bouche
Fibroblast Growth Factor-2 Binds to the Regulatory beta Subunit of CK2 and Directly Stimulates CK2 Activity toward Nucleolin
J. Biol. Chem., October 4, 1996; 271(40): 24781 - 24787.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
H. Haller, C. Lindschau, B. Erdmann, P. Quass, and F. C. Luft
Effects of Intracellular Angiotensin II in Vascular Smooth Muscle Cells
Circ. Res., October 1, 1996; 79(4): 765 - 772.
[Abstract] [Full Text]

Home page
 HypertensionHome page
L.-X. Zou, J. D. Imig, A. M. Von Thun, A. Hymel, H. Ono, and L. G. Navar
Receptor-Mediated Intrarenal Angiotensin II Augmentation in Angiotensin II–Infused Rats
Hypertension, October 1, 1996; 28(4): 669 - 677.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
I. A. Prudovsky, N. Savion, T. M. LaVallee, and T. Maciag
The Nuclear Trafficking of Extracellular Fibroblast Growth Factor (FGF)-1 Correlates with the Perinuclear Association of the FGF Receptor-1alpha Isoforms but Not the FGF Receptor-1beta Isoforms
J. Biol. Chem., June 14, 1996; 271(24): 14198 - 14205.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C.-Y. Xiao, S. Hübner, R. M. Elliot, A. Caon, and D. A. Jans
A Consensus cAMP-dependent Protein Kinase (PK-A) Site in Place of the CcN Motif Casein Kinase II Site of Simian Virus 40 Large T-antigen Confers PK-A-mediated Regulation of Nuclear Import
J. Biol. Chem., March 15, 1996; 271(11): 6451 - 6457.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-Z. Lin, S. Yao, and J. Hawiger
Role of the Nuclear Localization Sequence in Fibroblast Growth Factor-1-stimulated Mitogenic Pathways
J. Biol. Chem., March 8, 1996; 271(10): 5305 - 5308.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
L.-X. Zou, A. Hymel, J. D. Imig, and L. G. Navar
Renal Accumulation of Circulating Angiotensin II in Angiotensin II–Infused Rats
Hypertension, March 1, 1996; 27(3): 658 - 662.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
A. D. Everett, T. Stoops, and C. A. McNamara
Nuclear Targeting Is Required for Hepatoma-derived Growth Factor-stimulated Mitogenesis in Vascular Smooth Muscle Cells
J. Biol. Chem., September 28, 2001; 276(40): 37564 - 37568.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. L. Cook, Z. Zhang, and R. N. Re
In Vitro Evidence for an Intracellular Site of Angiotensin Action
Circ. Res., December 7, 2001; 89(12): 1138 - 1146.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by The Federation of American Societies for Experimental Biology.