The FASEB Journal, Vol 7, 551-557, Copyright © 1993 by The Federation of American Societies for Experimental Biology

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Choline phospholipids: signal transduction and carcinogenesis

SH Zeisel
Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill 27599-7400.

Phospholipids act as vital elements in transmembrane signaling. Agonist- induced hydrolysis of phosphatidylinositides has been established as a major mechanism for transmitting messages into the interior of cells via protein phosphorylation cascades, ultimately regulating gene transcription. There is a growing body of evidence that choline phospholipids (phosphatidylcholine, sphingomyelin, and their metabolites) also are important mediators and modulators of transmembrane signaling. These functions may explain how choline phospholipids influence normal physiological processes as well as a diverse group of pathological processes.

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