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The FASEB Journal, Vol 7, 420-426, Copyright © 1993 by The Federation of American Societies for Experimental Biology

REVIEWS

Role of the CD45 tyrosine phosphatase in signal transduction in the immune system

GA Koretzky
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242.

CD45, a family of hematopoietic cell specific surface antigens, is the best characterized protein tyrosine phosphatase described to date. Considerable evidence from a number of laboratories suggests that surface expression of this molecule is required for normal signaling events to occur in T lymphocytes, B lymphocytes, and natural killer cells. In this paper, data supporting this contention are reviewed and a model proposing how CD45 may exert its regulatory function on signal transduction via the T cell antigen receptor is presented.


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Copyright © 1993 by The Federation of American Societies for Experimental Biology.