The FASEB Journal, Vol 7, 328-338, Copyright © 1993 by The Federation of American Societies for Experimental Biology

REVIEWS

Intracellular cyclic GMP receptor proteins

TM Lincoln and TL Cornwell
Department of Pathology, University of Alabama, Birmingham 35294-0019.

Cyclic GMP is recognized as an important intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated ion channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. This means that cGMP can alter cell function through protein phosphorylation or through mechanisms not directly related to protein phosphorylation. Cyclic GMP appears to regulate a number of intracellular processes, such as vascular smooth muscle relaxation and neutrophil activation, through these receptor proteins in the cell. It is also becoming clear that the localization of these cGMP receptor proteins in the cell is an important factor in the regulation of cell function by cGMP.

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				J.-D. Chiche, S. M. Schlutsmeyer, D. B. Bloch, S. M. de la Monte, J. D. Roberts Jr., G. Filippov, S. P. Janssens, A. Rosenzweig, and K. D. Bloch Adenovirus-mediated Gene Transfer of cGMP-dependent Protein Kinase Increases the Sensitivity of Cultured Vascular Smooth Muscle Cells to the Antiproliferative and Pro-apoptotic Effects of Nitric Oxide/cGMP J. Biol. Chem., December 18, 1998; 273(51): 34263 - 34271. [Abstract] [Full Text] [PDF]

				L. A. Silveira, J. L. Smith, J. L. Tan, and J. A. Spudich MLCK-A, an unconventional myosin light chain kinase from Dictyostelium, is activated by a cGMP-dependent pathway PNAS, October 27, 1998; 95(22): 13000 - 13005. [Abstract] [Full Text] [PDF]

				Y. Geng, L. Zhou, W. J. Thompson, and M. Lotz Cyclic GMP and cGMP-binding Phosphodiesterase Are Required for Interleukin-1-induced Nitric Oxide Synthesis in Human Articular Chondrocytes J. Biol. Chem., October 16, 1998; 273(42): 27484 - 27491. [Abstract] [Full Text] [PDF]

				T. A. Wyatt, J. R. Spurzem, K. May, and J. H. Sisson Regulation of ciliary beat frequency by both PKA and PKG in bovine airway epithelial cells Am J Physiol Lung Cell Mol Physiol, October 1, 1998; 275(4): L827 - L835. [Abstract] [Full Text] [PDF]

				J. Hood and H. J. Granger Protein Kinase G Mediates Vascular Endothelial Growth Factor-induced Raf-1 Activation and Proliferation in Human Endothelial Cells J. Biol. Chem., September 4, 1998; 273(36): 23504 - 23508. [Abstract] [Full Text] [PDF]

				K. S. Murthy and G. M. Makhlouf cGMP-mediated Ca2+ release from IP3-insensitive Ca2+ stores in smooth muscle Am J Physiol Cell Physiol, May 1, 1998; 274(5): C1199 - C1205. [Abstract] [Full Text] [PDF]

				C. Cardillo, C. M. Kilcoyne, A. A. Quyyumi, R. O. Cannon III, and J. A. Panza Selective Defect in Nitric Oxide Synthesis May Explain the Impaired Endothelium-Dependent Vasodilation in Patients With Essential Hypertension Circulation, March 10, 1998; 97(9): 851 - 856. [Abstract] [Full Text] [PDF]

				S. A. Khan, N. R. Higdon, and K. D. Meisheri Coronary Vasorelaxation by Nitroglycerin: Involvement of Plasmalemmal Calcium-Activated K+ Channels and Intracellular Ca++ Stores J. Pharmacol. Exp. Ther., March 1, 1998; 284(3): 838 - 846. [Abstract] [Full Text]

				Arie. B. Vaandrager, A. Smolenski, B. C. Tilly, A. B. Houtsmuller, E. M. E. Ehlert, A. G. M. Bot, M. Edixhoven, W. E. M. Boomaars, S. M. Lohmann, and H. R. de Jonge Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl- channel activation PNAS, February 17, 1998; 95(4): 1466 - 1471. [Abstract] [Full Text] [PDF]

				B. Fouty, P. Komalavilas, M. Muramatsu, A. Cohen, I. F. McMurtry, T. M. Lincoln, and D. M. Rodman Protein kinase G is not essential to NO-cGMP modulation of basal tone in rat pulmonary circulation Am J Physiol Heart Circ Physiol, February 1, 1998; 274(2): H672 - H678. [Abstract] [Full Text] [PDF]

				P. Carvalho, S. R. Johnson, and N. B. Charan Non-cAMP-mediated bronchial arterial vasodilation in response to inhaled beta -agonists J Appl Physiol, January 1, 1998; 84(1): 215 - 221. [Abstract] [Full Text] [PDF]

				C. Cardillo, C. M. Kilcoyne, A. A. Quyyumi, R. O. Cannon III, and J. A. Panza Decreased Vasodilator Response to Isoproterenol During Nitric Oxide Inhibition in Humans Hypertension, October 1, 1997; 30(4): 918 - 921. [Abstract] [Full Text]

				T. Syrovets, B. Tippler, M. Rieks, and T. Simmet Plasmin Is a Potent and Specific Chemoattractant for Human Peripheral Monocytes Acting Via a Cyclic Guanosine Monophosphate-Dependent Pathway Blood, June 15, 1997; 89(12): 4574 - 4583. [Abstract] [Full Text] [PDF]

				Q. Lin, Y. B. Peng, J. Wu, and W. D. Willis Involvement of cGMP in Nociceptive Processing by and Sensitization of Spinothalamic Neurons in Primates J. Neurosci., May 1, 1997; 17(9): 3293 - 3302. [Abstract] [Full Text] [PDF]