FASEB J. Pierce now sold as Thermo Scientific
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Beinert, H.
Right arrow Articles by Kennedy, M. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Beinert, H.
Right arrow Articles by Kennedy, M. C.

The FASEB Journal, Vol 7, 1442-1449, Copyright © 1993 by The Federation of American Societies for Experimental Biology

REVIEWS

Aconitase, a two-faced protein: enzyme and iron regulatory factor

H Beinert and MC Kennedy
Department of Biochemistry, Medical College of Wisconsin, Milwaukee 53226.

In this brief survey, the path of development of our knowledge of the iron-sulfur enzyme aconitase [citrate(isocitrate)hydrolyase EC4.2.1.3.] is traced from its discovery in 1937. Particular emphasis is on developments in the past decade, when EPR, Mossbauer and electron nuclear double resonance spectroscopies, X-ray crystallography, and mutational analysis were applied to the problem. More recently discovered was the significant amino acid sequence identity between mitochondrial aconitase and the iron regulatory factor or iron- responsive element binding protein (IRE-BP). This has led to the realization that IRE-BP is an alternative form of cytosolic (not of mitochondrial) aconitase that is devoid of its cubane Fe-S cluster.


This article has been cited by other articles:


Home page
 Microbiol. Mol. Biol. Rev.Home page
C. Gancedo and C.-L. Flores
Moonlighting Proteins in Yeasts
Microbiol. Mol. Biol. Rev., March 1, 2008; 72(1): 197 - 210.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
S. Banerjee, A. K. Nandyala, P. Raviprasad, N. Ahmed, and S. E. Hasnain
Iron-Dependent RNA-Binding Activity of Mycobacterium tuberculosis Aconitase
J. Bacteriol., June 1, 2007; 189(11): 4046 - 4052.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
A. A. Cherkasov, R. A. Overton Jr, E. P. Sokolov, and I. M. Sokolova
Temperature-dependent effects of cadmium and purine nucleotides on mitochondrial aconitase from a marine ectotherm, Crassostrea virginica: a role of temperature in oxidative stress and allosteric enzyme regulation
J. Exp. Biol., January 1, 2007; 210(1): 46 - 55.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Schranzhofer, M. Schifrer, J. A. Cabrera, S. Kopp, P. Chiba, H. Beug, and E. W. Mullner
Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis
Blood, May 15, 2006; 107(10): 4159 - 4167.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
R. Stocker and J. F. Keaney Jr.
Role of Oxidative Modifications in Atherosclerosis
Physiol Rev, October 1, 2004; 84(4): 1381 - 1478.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
J. C. Kwok and D. R. Richardson
Unexpected Anthracycline-Mediated Alterations in Iron-Regulatory Protein-RNA-Binding Activity: The Iron and Copper Complexes of Anthracyclines Decrease RNA-Binding Activity
Mol. Pharmacol., October 1, 2002; 62(4): 888 - 900.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Bouton, M.-J. Chauveau, S. Lazereg, and J.-C. Drapier
Recycling of RNA Binding Iron Regulatory Protein 1 into an Aconitase after Nitric Oxide Removal Depends on Mitochondrial ATP
J. Biol. Chem., August 16, 2002; 277(34): 31220 - 31227.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Yamaguchi-Iwai, R. Ueta, A. Fukunaka, and R. Sasaki
Subcellular Localization of Aft1 Transcription Factor Responds to Iron Status in Saccharomyces cerevisiae
J. Biol. Chem., May 17, 2002; 277(21): 18914 - 18918.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. E. Walden
From bacteria to mitochondria: Aconitase yields surprises
PNAS, April 2, 2002; 99(7): 4138 - 4140.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Minotti, R. Ronchi, E. Salvatorelli, P. Menna, and G. Cairo
Doxorubicin Irreversibly Inactivates Iron Regulatory Proteins 1 and 2 in Cardiomyocytes: Evidence for Distinct Metabolic Pathways and Implications for Iron-mediated Cardiotoxicity of Antitumor Therapy
Cancer Res., December 1, 2001; 61(23): 8422 - 8428.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. Van Remmen, M. D. Williams, Z. Guo, L. Estlack, H. Yang, E. J. Carlson, C. J. Epstein, T. T. Huang, and A. Richardson
Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis
Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1422 - H1432.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. K. Nanda and J. L. Leibowitz
Mitochondrial Aconitase Binds to the 3' Untranslated Region of the Mouse Hepatitis Virus Genome
J. Virol., April 1, 2001; 75(7): 3352 - 3362.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
L. T. Jensen and V. C. Culotta
Role of Saccharomyces cerevisiae ISA1 and ISA2 in Iron Homeostasis
Mol. Cell. Biol., June 1, 2000; 20(11): 3918 - 3927.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
S. Kim and P. Ponka
Effects of Interferon-gamma and Lipopolysaccharide on Macrophage Iron Metabolism Are Mediated by Nitric Oxide-induced Degradation of Iron Regulatory Protein 2
J. Biol. Chem., February 25, 2000; 275(9): 6220 - 6226.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Pourzand, R. D. Watkin, J. E. Brown, and R. M. Tyrrell
Ultraviolet A radiation induces immediate release of iron in human primary skin fibroblasts: The role of ferritin
PNAS, June 8, 1999; 96(12): 6751 - 6756.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
G. MINOTTI, G. CAIRO, and E. MONTI
Role of iron in anthracycline cardiotoxicity: new tunes for an old song?
FASEB J, February 1, 1999; 13(2): 199 - 212.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
L. Oliveira, C. Bouton, and J.-C. Drapier
Thioredoxin Activation of Iron Regulatory Proteins. REDOX REGULATION OF RNA BINDING AFTER EXPOSURE TO NITRIC OXIDE
J. Biol. Chem., January 1, 1999; 274(1): 516 - 521.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
G. CAIRO, L. TACCHINI, S. RECALCATI, B. AZZIMONTI, G. MINOTTI, and A. BERNELLI-ZAZZERA
Effect of Reactive Oxygen Species on Iron Regulatory Protein Activity
Ann. N.Y. Acad. Sci., June 30, 1998; 851(1): 179 - 186.
[Full Text] [PDF]

Home page
 FASEB J.Home page
G. Minotti, S. Recalcati, A. Mordente, G. Liberi, A. M. Calafiore, C. Mancuso, P. Preziosi, and G. Cairo
The secondary alcohol metabolite of doxorubicin irreversibly inactivates aconitase/iron regulatory protein-1 in cytosolic fractions from human myocardium
FASEB J, May 1, 1998; 12(7): 541 - 552.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. J. Ghio, J. D. Carter, J. M. Samet, W. Reed, J. Quay, L. A. Dailey, J. H. Richards, and R. B. Devlin
Metal-dependent expression of ferritin and lactoferrin by respiratory epithelial cells
Am J Physiol Lung Cell Mol Physiol, May 1, 1998; 274(5): L728 - L736.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Benov and I. Fridovich
Growth in Iron-enriched Medium Partially Compensates Escherichia coli for the Lack of Manganese and Iron Superoxide Dismutase
J. Biol. Chem., April 24, 1998; 273(17): 10313 - 10316.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Bouton, L. Oliveira, and J.-C. Drapier
Converse Modulation of IRP1 and IRP2 by Immunological Stimuli in Murine RAW 264.7 Macrophages
J. Biol. Chem., April 17, 1998; 273(16): 9403 - 9408.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. J. Ghio, J. D. Carter, J. H. Richards, L. E. Brighton, J. C. Lay, and R. B. Devlin
Disruption of normal iron homeostasis after bronchial instillation of an iron-containing particle
Am J Physiol Lung Cell Mol Physiol, March 1, 1998; 274(3): L396 - L403.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. J. Ghio, J. D. Carter, J. M. Samet, J. Quay, I. A. Wortman, J. H. Richards, T. P. Kennedy, and R. B. Devlin
Ferritin Expression after In Vitro Exposures of Human Alveolar Macrophages to Silica Is Iron-dependent
Am. J. Respir. Cell Mol. Biol., November 1, 1997; 17(5): 533 - 540.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
Céc. Bouton, M. Raveau, and J.-C. Drapier
Modulation of Iron Regulatory Protein Functions
J. Biol. Chem., January 26, 1996; 271(4): 2300 - 2306.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Guo, J. D. Phillips, Y. Yu, and E. A. Leibold
Iron Regulates the Intracellular Degradation of Iron Regulatory Protein 2 by the Proteasome
J. Biol. Chem., September 15, 1995; 270(37): 21645 - 21651.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. M. Izquierdo, J. Ricart, L. K. Ostronoff, G. Egea, and J. M. Cuezva
Changing Patterns of Transcriptional and Post-transcriptional Control of [IMAGE]-F[IMAGE]-ATPase Gene Expression during Mitochondrial Biogenesis in Liver
J. Biol. Chem., April 28, 1995; 270(17): 10342 - 10350.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Oliveira and J.-C. Drapier
Down-regulation of iron regulatory protein 1 gene expression by nitric oxide
PNAS, June 6, 2000; 97(12): 6550 - 6555.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1993 by The Federation of American Societies for Experimental Biology.